Research Paper Volume 13, Issue 3 pp 3843—3865

Figure 2. Associations of surviving methylation sites with metabolic traits and hyperuricemia. The graphical representation shows monocyte-specific associations between cg22626579, cg10314750, cg03795507, cg10257063, cg16975613, cg16630982, cg12182452, cg17151991, cg26375855 methylation and low density lipoprotein (blue line), triglyceride (red line), HbA_1c levels (cyan line) and hyperuricemia (green line). The radii mean minus log₁₀P of monocyte-specific associations between cytosine-phosphate-guanine dinucleotide (CpG) sites and phenotypes. The dashed purple circle shows threshold value of P=0.05. For example, cg17151991 is not monocyte-specifically associated with low density lipoprotein (P=0.6650, minus log₁₀P=0.18), triglyceride (P=0.3715, minus log₁₀P=0.43), HbA_1c (P=0.5758, minus log₁₀P=0.24) and hyperuricemia (P=0.2481, minus log₁₀P=0.61). All results are adjusted for sex, age, alcohol drinking, smoking status, smoking history (total pack-years) and cell fractions with CellDMC (see supplementary methods).