Figure 3. Subgroup and joint-effect analysis of AKR1C3 and AKR1D1. (A, B) High expression of AKR1C3 suggested poor prognosis in the early and advanced TNM stage. (C, D) Low expression of AKR1D1 was related to poor prognosis in male and female. (E) Joint-effect analysis of AKR1C3 and AKR1D1.