Research Paper Volume 13, Issue 3 pp 4242—4257
Oxaliplatin induces the PARP1-mediated parthanatos in oral squamous cell carcinoma by increasing production of ROS
Figure 1. Oxaliplatin inhibited cell viability, migration and cloning formation of OSCC cells and induced cell death in vitro. (A) Chemical structure of oxaliplatin. (B, C) Cell viability of CAL27 and SCC25 cells treated with different concentrations of oxaliplatin for 12, 24, and 48 hours. (D, E) The colony formation assay of CAL27 and SCC25 cells treated with oxaliplatin for 10 days. (F–I) The wound healing detection of CAL27 and SCC25 cells treated with different concentrations of oxaliplatin for 12, 24, and 36 hours. (J, K) The cell death ratio based on LDH release assay of CAL27 and SCC25 cells treated with 125 μM and 100 μM oxaliplatin. * p<0.05, **p<0.01.