Integrated analysis of microRNA and mRNA expression profiling identifies <i>BAIAP3</i> as a novel target of dysregulated hsa-miR-1972 in age-related white matter lesions

Wen-Qing Huang; Qing Lin; Shuai Chen; Lixiang Sun; Qingjie Chen; Kehui Yi; Zhi Li; Qilin Ma; Chi-Meng Tzeng

doi:doi:10.18632/aging.202562

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Research Paper Volume 13, Issue 3 pp 4674—4695

Integrated analysis of microRNA and mRNA expression profiling identifies BAIAP3 as a novel target of dysregulated hsa-miR-1972 in age-related white matter lesions

Figure 2. TaqMan-qPCR analysis of differentially expressed miRNA during LA onset. Four miRNAs are differentially expressed during LA onset including hsa-miR-1972, hsa-miR-26b-5p, hsa-miR-3141, and hsa-miR-623. They were selected from miRNA microarray analysis data and identified in independent type I LA samples using ABI TaqMan probe-based qPCR technology. The study showed significant down-regulation of hsa-miR-1972, hsa-miR-26b-5p, and hsa-miR-3141 in independent subjects with type I LA (n=12) compared with controls (n=12), ^*P < 0.05, ^*P < 0.01.