Research Paper Volume 13, Issue 11 pp 14843—14861
TP73-AS1 is induced by YY1 during TMZ treatment and highly expressed in the aging brain
Figure 3. TP73-AS1 is induced by TMZ. (A) TP73-AS1 levels in the indicated cell lines were measured using qRT-PCR. * p<0.05 in the two-tailed t-test. (B) The genomic region of the putative TP73-AS1 promoter was identified using the UCSC browser. H3K27 acetylation and TF ChIP-SEQ data obtained from ENCODE are shown. Transcriptional start site (TSS), intron 1, and exon 1 are shown. The two promoter regions used in this study are highlighted. (C) Promoter activity assay was performed in the indicated cell lines using the dual luciferase assay. * p<0.05 in the two tailed t-test. (D) Promoter activity assay was performed in the indicated cell lines using the dual luciferase assay. * p<0.05 in the two tailed t-test.