Research Paper Volume 14, Issue 2 pp 747—769
Overexpression of chaperonin containing TCP1 subunit 7 has diagnostic and prognostic value for hepatocellular carcinoma
Figure 5. CCT7 has better diagnostic value than AFP for HCC patients with low AFP expression and early-stage disease. (A, B) AFP (A) and CCT7 (B) mRNA expression in tissues from cirrhosis patients (n = 40) and HCC patients with low AFP expression (n = 134) in the GSE25097 dataset. (C) ROC curve analysis showing the diagnostic value of AFP and CCT7 in HCC patients with low AFP expression in the GSE25097 dataset. (D, E) AFP (D) and CCT7 (E) mRNA expression in tissues from cirrhosis patients (n = 168) and HCC patients with low AFP expression (n = 185) in the GSE63898 dataset. (F) ROC curve analysis showing the diagnostic value of AFP and CCT7 in HCC patients with low AFP expression in the GSE63898 dataset. (G) ROC curve analysis showing the diagnostic value of AFP and CCT7 in stage 1 HCC patients from TCGA. (H) The PPV and NPV of AFP and CCT7 in stage 1 HCC patients from TCGA. (I–L) The correlations of CCT7 levels with AFP (I), ACE (J), GPC3 (K) and GPT (L) levels.