Research Paper Volume 14, Issue 2 pp 572—595

Combination of dasatinib and quercetin improves cognitive abilities in aged male Wistar rats, alleviates inflammation and changes hippocampal synaptic plasticity and histone H3 methylation profile


Figure 3. D+Q treatment changes synaptic plasticity in the apical dendrites of neurons of the CA1 region of the hippocampus. Representative images of DiI stained dendrites (A and B). DiI stained hippocampal slices from aged vehicle (grey bars) or D+Q (red bars) treated rats were used for the analysis of synaptic plasticity. Different parameters of the dendritic spine shape (length, length to width ratio, area, circumference C and D) and spine density (E and F) were analyzed in the CA1 region of the hippocampus. The analysis was done for two dendritic arbours of stratum pyramidale, namely basal (BASAL) (D and F) and apical (APICAL) dendrites (C and E). The data are expressed as mean ± SEM, and analyzed using nested t-test. Dots on the bar plots represent values for single dendritic spines (C and D) or single image (E and F) NVEH = 3, ND+Q = 5 animals, *p < 0.05, **p < 0.01, ***p < 0.001.