Research Paper Volume 14, Issue 4 pp 1836—1847

Figure 3. The luciferase activities of KCNQ1OT1 and ATG4B were repressed by miR-34a. (A) Sequence analysis indicated potential binding of miR-34a to KCNQ1OT1. (B) The luciferase activity of KCNQ1OT1 was suppressed by miR-34a in HCT116 cells (statistical analysis: one-way ANOVA; * P value < 0.05, F value = 10.17 vs. control group). (C) The luciferase activity of KCNQ1OT1 was suppressed by miR-34a in SW480 cells (statistical analysis: one-way ANOVA; * P value < 0.05, F value = 6.29 vs. control group). (D) Sequence analysis indicated potential binding of miR-34a to ATG4B. (E) The luciferase activity of ATG4B was suppressed by miR-34a in HCT116 cells (statistical analysis: one-way ANOVA; * P value < 0.05, F value = 7.24 vs. control group). (F) The luciferase activity of K ATG4B was suppressed by miR-34a in SW480 cells (statistical analysis: one-way ANOVA; * P value < 0.05, F value = 11.69 vs. control group).