Research Paper Volume 14, Issue 4 pp 1932—1940
Different tumorigenicity and distinct metastasis and gene signature between orthotopic and subcutaneous neuroblastoma xenografted mice
Figure 2. Tumor metastasis in orthotopic and subcutaneous CDX mice. (A) Representative image of orthotopic CDX mice was taken at day 14 after cell implantation (Mice used, n = 6, Representative data used, n = 1). (B) Representative bioluminescence images of tumors in orthotopic CDX mice (Mice used, n = 6, Representative data used, n = 2). (C) Representative bioluminescence images for the metastatic liver, lung, spleen and intestine in orthotopic CDX mice (Mice used, n = 6, Representative data used, n = 2). (D) Representative image of subcutaneous CDX mice were taken at day 21 after cell implantation (Mice used, n = 5, Representative data used, n = 1). (E) Representative bioluminescence images of tumors in subcutaneous CDX mice (Mice used, n = 5, Representative data used, n = 2). (F) Representative bioluminescence images for the metastatic liver, lung, spleen and intestine in subcutaneous CDX mice (Mice used, n = 5, Representative data used, n = 2). (G) Representative images for the kidneys and the adrenal glands were injected with or without cells (two kidneys from one CDX mouse). Left: Kidney without cell injection. Right: Kidney with cell injection.