Research Paper Volume 15, Issue 6 pp 1859—1877
P53/miR-34a/SIRT1 positive feedback loop regulates the termination of liver regeneration
Figure 6. The expression of the P53/miR-34a/SIRT1 positive feedback loop in hepatocellular carcinoma patients. (A) A brief diagram of how 92 HCC patients were divided. (B) The 5-year survival rate of HCC patients from different groups. (p = 0.036, Green: P53-mutated vs P53-wild-type patients. p = 0.027, Red: P53-deficient vs P53-wild-type patients, log-rank test). (C) Representative images of P53 staining in P53-mutated patients. (D) Protein expression of the P53/miR-34a/SIRT1 positive feedback loop in P53-mutated patient tumor tissue. (E) Quantification of hepatic miR-34a expression in P53-mutated patient tumor tissue.