Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

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Volume 15, Issue 6

31 March, 2023
pp 1704—2361

About the Cover

The cover features Figure 5 " MET+LEU reduced inflammatory transcriptional profile and markers of cellular senescence" from Petrocelli et al

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Editorials

Senolytics improve muscle adaptation in old mice

Cory M. Dungan, Charlotte A. Peterson,

https://doi.org/10.18632/aging.204578 pp 1704—1705

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Socioeconomic inequalities in the Pace of Aging

Stephanie Schrempft, Silvia Stringhini,

https://doi.org/10.18632/aging.204595 pp 1706—1707

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Chronic orofacial pain and white matter hyperintensities

Elena Calabria, Federica Canfora, Daniela Adamo,

https://doi.org/10.18632/aging.204584 pp 1708—1710

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Potential of Urolithin A to improve joint health

Davide D’Amico, Martin Lotz,

https://doi.org/10.18632/aging.204633 pp 1711—1712

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Research Papers

Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells

Tu Nguyen, Daniel Urrutia-Cabrera, Luozixian Wang, Jarmon G. Lees, Jiang-Hui Wang, Sandy S.C. Hung, Alex W. Hewitt, Thomas L. Edwards, Sam McLenachan, Fred K. Chen, Shiang Y. Lim, Chi D. Luu, Robyn Guymer, Raymond C.B. Wong,

https://doi.org/10.18632/aging.204522 pp 1713—1733

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Selenium as a predictor of metabolic syndrome in middle age women

Daria Schneider-Matyka, Anna Maria Cybulska, Małgorzata Szkup, Bogumiła Pilarczyk, Mariusz Panczyk, Agnieszka Tomza-Marciniak, Elżbieta Grochans,

https://doi.org/10.18632/aging.204590 pp 1734—1747

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RNA virus-mediated changes in organismal oxygen consumption rate in young and old Drosophila melanogaster males

Eli Hagedorn, Dean Bunnell, Beate Henschel, Daniel L. Smith Jr., Stephanie Dickinson, Andrew W. Brown, Maria De Luca, Ashley N. Turner, Stanislava Chtarbanova,

https://doi.org/10.18632/aging.204593 pp 1748—1767

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Brief, weekly magnetic muscle therapy improves mobility and lean body mass in older adults: a Southeast Asia community case study

Sharanya Venugobal, Yee Kit Tai, Jorming Goh, Sean Teh, Craig Wong, Ivan Goh, Andrea B. Maier, Brian K. Kennedy, Alfredo Franco-Obregón,

https://doi.org/10.18632/aging.204597 pp 1768—1790

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PD-L1^ATTAC mice reveal the potential of depleting PD-L1 expressing cells in cancer therapy

Elena Fueyo-Marcos, Gema Lopez-Pernas, Coral Fustero-Torre, Marta Elena Antón, Fátima Al-Shahrour, Oscar Fernández-Capetillo, Matilde Murga,

https://doi.org/10.18632/aging.204598 pp 1791—1807

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Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail

Jonathan J. Petrocelli, Naomi M.M.P. de Hart, Marisa J. Lang, Elena M. Yee, Patrick J. Ferrara, Dennis K. Fix, Amandine Chaix, Katsuhiko Funai, Micah J. Drummond,

https://doi.org/10.18632/aging.204600 pp 1808—1832

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Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series

Kara N. Fitzgerald, Tish Campbell, Suzanne Makarem, Romilly Hodges,

https://doi.org/10.18632/aging.204602 pp 1833—1839

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Adiponectin is associated with inflammaging and age-related salivary gland lipid accumulation

Ji Won Kim, Jeong Mi Kim, Mi Eun Choi, Eun Jeong Jeon, Jin-Mi Park, Young-Mo Kim, Jeong-Seok Choi,

https://doi.org/10.18632/aging.204618 pp 1840—1858

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P53/miR-34a/SIRT1 positive feedback loop regulates the termination of liver regeneration

Junhua Gong, Minghua Cong, Hao Wu, Menghao Wang, He Bai, Jingyuan Wang, Keting Que, Kaiwen Zheng, Wenfeng Zhang, Xiaoli Yang, Jianping Gong, Hanping Shi, Mingyong Miao, Fangchao Yuan,

https://doi.org/10.18632/aging.203920 pp 1859—1877

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A multi-omics approach based on ¹H-NMR metabonomics combined with target protein analysis to reveal the mechanism of RIAISs on cervical carcinoma patients

Chai Yanlan, Aibibai Jielili, Juan Wang, Haiying Tang, Zi Liu, Ping Wang,

https://doi.org/10.18632/aging.204305 pp 1878—1889

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The study of antecedent clinical manifestations of hypertensive heart disease in cohort of hypertension

Qian Li, Na Li, Xiao Liang, Yanjie Liu, Li Chen, Huimin Lao, Sheng Wei, Jun Xiao, Xiaoqiang Qi,

https://doi.org/10.18632/aging.204510 pp 1890—1917

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Haplotype-GGGT in long non-coding RNA MALAT1 inhibits brain metastatic lung cancer and lymph nodes of lung cancer via the MALAT1/miR-328/KATNB1

Tingting Liu, Jianpeng Ma, Dongmei Hou, Weiqi Wang, Hetao Cao,

https://doi.org/10.18632/aging.204563 pp 1918—1930

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Exosomal miR-370-3p increases the permeability of blood-brain barrier in ischemia/reperfusion stroke of brain by targeting MPK1

Caifeng Gu, Weichun Mo, Kunlun Wang, Mingqiang Gao, Junfeng Chen, Feng Zhang, Jie Shen,

https://doi.org/10.18632/aging.204573 pp 1931—1943

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Development a m⁶A regulators characterized by the immune cell infiltration in stomach adenocarcinoma for predicting the prognosis and immunotherapy response

Guodong Shi, Yang Li, Huijiang Gao, Yucheng Wei, Yuanyong Wang,

https://doi.org/10.18632/aging.204574 pp 1944—1963

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Clinical significance and integrative analysis of the cuproptosis-associated genes in head and neck squamous cell carcinoma

Qiu Peng, Xianjie Jiang, Shiming Tan, Xuemeng Xu, Longzheng Xia, Nayiyuan Wu, Jinguan Lin, Linda Oyang, Yanyan Tang, Mingjing Peng, Min Su, Xia Luo, Yaqian Han, Qianjin Liao, Yujuan Zhou,

https://doi.org/10.18632/aging.204579 pp 1964—1976

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Hsp22 pretreatment protects against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice

Shengliang Peng, Yun Yu, Juan Li, Danling Jiang, Guohai Xu, Lidong Wu, Jialing Hu,

https://doi.org/10.18632/aging.204586 pp 1977—2004

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Association between the sarcopenia index and the risk of stroke in elderly patients with hypertension: a cohort study

Xintian Cai, Junli Hu, Mengru Wang, Wen Wen, Jingyu Wang, Wenbo Yang, Yujie Dang, Qin Luo, Jing Hong, Nanfang Li,

https://doi.org/10.18632/aging.204587 pp 2005—2032

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Epimedin C protects dexamethasone-induced osteoblasts through NRF1/RhoA pathway

Mi Huang, Lei Yu, Ying Wang, Chunlin Yang,

https://doi.org/10.18632/aging.204588 pp 2033—2045

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Baixiangdan capsule and Shuyu capsule regulate anger-out and anger-in, respectively: GB1–mediated GABA can regulate 5-HT levels in multiple brain regions

Xiaoju Liu, Haijuan Wang, Xiaoyu Wang, Yinxia Ning, Wei Liu, Jie Gao,

https://doi.org/10.18632/aging.204589 pp 2046—2065

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Characterization of SHCBP1 to prognosis and immunological landscape in pan-cancer: novel insights to biomarker and therapeutic targets

Fei Jiang, Yanlong Shi, Yue Wang, Chang Ge, Jun Zhu, Hanlu Fang, Yu Zhang, Yixiao Zhang, Haokun Jian, Tong Lei, Sheng Lan, Liyu Cao, Hongzhu Yu, Debao Fang,

https://doi.org/10.18632/aging.204591 pp 2066—2081

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Single cell sequencing analysis constructed the N7-methylguanosine (m7G)-related prognostic signature in uveal melanoma

Jiaheng Xie, Liang Chen, Yuan Cao, Chenfeng Ma, Wenhu Zhao, JinJing Li, Wen Yao, Yiming Hu, Ming Wang, Jingping Shi,

https://doi.org/10.18632/aging.204592 pp 2082—2096

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ADAMTS1 induces epithelial-mesenchymal transition pathway in non-small cell lung cancer by regulating TGF-β

Xueqian Hu, Chunqi Jiang, Ning Hu, Shanyi Hong,

https://doi.org/10.18632/aging.204594 pp 2097—2114

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Pan-cancer analysis reveals the associations between MMP13 high expression and carcinogenesis and its value as a serum diagnostic marker

Xinhui Zhang, Qingmei Deng, Xiaofeng Wan, Jingyu Zhao, Xin Zheng, Hongzhi Wang, Hong-Qiang Wang, Wulin Yang,

https://doi.org/10.18632/aging.204599 pp 2115—2135

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The cell senescence regulator p16 is a promising cancer prognostic and immune check-point inhibitor (ICI) therapy biomarker

Zewei Tu, Xiaolin Wang, Huan Cai, Yilei Sheng, Lei Wu, Kai Huang, Xingen Zhu,

https://doi.org/10.18632/aging.204601 pp 2136—2157

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Reduction of NgR in perforant path protects neuronal morphology and function in APP/PS1 transgenic mice

Rong Jiang, Xiao-Dong Chi, Yulong Jing, Bin Wang, Shao Li,

https://doi.org/10.18632/aging.204605 pp 2158—2169

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Expression profile and prognostic values of GATA family members in kidney renal clear cell carcinoma

Xuejie Yang, Cheng Mei, Hui Nie, Jianhua Zhou, Chunlin Ou, Xiaoyun He,

https://doi.org/10.18632/aging.204607 pp 2170—2188

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Combating pancreatic cancer with ovarian cancer cells

Xiao Lin, Chunmei Cui, Qinghua Cui,

https://doi.org/10.18632/aging.204608 pp 2189—2207

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GALNT2 sustains glioma stem cells by promoting CD44 expression

Yingying Liu, Peisheng Chen, Liufei Xu, Bo Wang, Shengping Zhang, Xiangpeng Wang,

https://doi.org/10.18632/aging.204609 pp 2208—2220

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Promising antitumor effects of the curcumin analog DMC-BH on colorectal cancer cells

Gang Liu, Jian Chen, Zhicheng Bao,

https://doi.org/10.18632/aging.204610 pp 2221—2236

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A network meta-analysis of the efficacy of hypoxia-inducible factor prolyl-hydroxylase inhibitors in dialysis chronic kidney disease

Jun Chen, Xinyang Shou, Yanyan Xu, Lie Jin, Chaoyong Zhu, Xiaolan Ye, Ziwei Mei, Peipei Chen,

https://doi.org/10.18632/aging.204611 pp 2237—2274

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PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway

Xingang Cui, Xiaoyang Liu, Peng Kong, Ting Du, Tao Li, Guihe Yang, Weimin Zhang, Xingzhi Jing, Wenchao Wang,

https://doi.org/10.18632/aging.204612 pp 2275—2292

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Construction and validation of a hypoxia-related risk signature identified EXO1 as a prognostic biomarker based on 12 genes in lung adenocarcinoma

Qirui Chen, Shuo Chen, Jing Wang, Yan Zhao, Xin Ye, Yili Fu, Yi Liu,

https://doi.org/10.18632/aging.204613 pp 2293—2307

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Curcumin (CUMINUP60®) mitigates exercise fatigue through regulating PI3K/Akt/AMPK/mTOR pathway in mice

Minghui Hu, Muxuan Han, Hao Zhang, Zifa Li, Kaiyong Xu, Huaixing Kang, Jiancheng Zong, Feng Zhao, Yuanxiang Liu, Wei Liu,

https://doi.org/10.18632/aging.204614 pp 2308—2320

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Downregulated annexin A1 expression correlates with poor prognosis, metastasis, and immunosuppressive microenvironment in Ewing’s sarcoma

Xiangwen Shi, Yipeng Wu, Linmeng Tang, Haonan Ni, Yongqing Xu,

https://doi.org/10.18632/aging.204615 pp 2321—2346

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MiR-320b aberrant expression enhances the radioresistance of human glioma via upregulated expression of ALDH1A3

Ping Mao, Tuo Wang, Ke Gao, Yi Li, Changwang Du, Maode Wang,

https://doi.org/10.18632/aging.204617 pp 2347—2357

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Corrections

Correction for: Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF

Xiao-Lin Jiang, He Tai, Jin-Song Kuang, Jing-Yi Zhang, Shi-Chao Cui, Yu-Xuan Lu, Shu-Bo Qi, Shi-Yu Zhang, Shun-Min Li, Jian-Ping Chen, Xian-Sheng Meng,

https://doi.org/10.18632/aging.204637 pp 2358—2360

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Correction for: A novel fatty-acid metabolism-based classification for triple negative breast cancer

Xia Yang, Wen Tang, Yongtao He, Huimin An, Jin Wang,

https://doi.org/10.18632/aging.204638 pp 2361

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