Research Paper Volume 14, Issue 8 pp 3446—3463

Figure 4. Network analysis identified CXCL14 as a key cytokine gene. (A–C) showed the gene co-expression networks of differentially expressed cytokines and other genes in Hodgkin's lymphoma, diffuse large B-cell lymphoma, and mantle cell lymphoma. Cytokine-gene pairs with correlation coefficients higher than 0.7 were chosen to build the network. The red circles represent the cytokines. The orange, blue and green circles represent the genes in each type of lymphoma. The size of the circle indicates the number of nodes. (D) Functional interaction network analysis of CXCL14. The network shows the CXCL14 related genes and their functions. Each color line represents a different interaction; the color line width indicates the weight of the interactions. There were 5 significantly enriched biological functions and the grey line indicates the gene is involved in the biological function.