Figure 3. Age and sex-specific prevalence of enlarged perivascular spaces (ePVS) stratified by brain topography (basal ganglia and centrum semiovale). Notice the increase prevalence of high burden ePVS (grades III and IV, orange and red color bars) with age starting around 50-60 years, and the decreasing prevalence of low burden ePVS (grades I and II, green and yellow bars) as age increases from younger age groups, becoming uncommon in the elderly.