Figure 4. Age- and sex-specific prevalence of mixed (CSO and/or BG) high burden enlarge perivascular spaces. High ePVS burden was defined as grades III and IV within each region. The mixed score reflects participants with no high ePVS burden in neither the Basal Ganglia or Centrum Semiovale (grade 0, green color bar), high ePVS burden in either the Basal Ganglia or the Centrum Semiovale (grade 1, orange color bar), and high burden in both the Centrum Semiovale and the Basal Ganglia (grade 2, dark red color bar). Notice that high burden in both regions increases with age, beginning in the 50-60 age group.