Research Paper Volume 14, Issue 16 pp 6689—6715
Prognostic alternative splicing events related splicing factors define the tumor microenvironment and pharmacogenomic landscape in lung adenocarcinoma
Figure 6. Construction of SFs signatures. (A) 4819 SFs-related differentially expressed genes (DEGs) between three distinct SFs patterns were presented in the Venn diagram. (B) Consensus clustering matrix for k = 3. (C) Principal component analysis (PCA) for the transcriptome profiles of gene cluster A, B. (D) Survival analysis for the two gene clusters based on 2959 SFs-related DEGs in GEO cohorts (P < 0.001). (E) TME cell infiltrating abundances in two gene clusters. (F) Difference of immune functions in two gene clusters. (G) Difference of other tumor-related biological processes.