Research Paper Volume 14, Issue 16 pp 6689—6715
Prognostic alternative splicing events related splicing factors define the tumor microenvironment and pharmacogenomic landscape in lung adenocarcinoma
Figure 8. Characteristics of SFscore in tumor somatic mutation. (A) Differences in tumor mutation burden (TMB) between low and high SFscore groups of TCGA cohort (P < 0.001). (B) Correlations between SFscore and TMB using Spearman analysis (R = −0.36, P < 0.001). (C) Survival analyses for subgroup patients stratified by both SFscore and TMB using Kaplan-Meier curves. H-TMB, high TMB; L-TMB, low TMB (P < 0.001, Log-rank test). (D) The waterfall plot of tumor somatic mutation established by those with low SFscore. (E) The waterfall plot of tumor somatic mutation based on LUAD samples with high SFscore.