Research Paper Volume 14, Issue 17 pp 6917—6935
Identification of immune subtypes to guide immunotherapy and targeted therapy in clear cell renal cell carcinoma
Figure 5. Analysis and definition of biological and immunological characteristics of IS2. (A) Differential enrichment analysis of signaling pathways in IS2 compared with IS1 and IS3 in TCGA cohorts. (B) Differential expression of the TGF-β pathway and key regulators (SMAD2 and SMAD3) among immune-related subtypes. (C) Differential expression of the ANGIOGENESIS pathway and major regulatory genes among immune-related subtypes. (D) Differential expression of the REACTOME SIGNALING BY RECEPTOR TYROSINE KINASES pathway and major regulatory genes among immune-related subtypes.