Research Paper Volume 14, Issue 19 pp 7650—7661
Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle
Figure 2. Macrophages in mdx/utro(−/−) muscle exhibits higher level of mTOR activation. (A) Immunofluorescent staining of CD68 and p-4E-BP1 in muscle tissues of WT and mdx/utro(−/−) mice. (B) Immunofluorescent staining of p-4E-BP1 in macrophages isolated from muscle tissues of WT and mdx/utro(−/−) mice. (C) Statistics of results in vivo. n = 8 mice/group. Data are presented as mean +/− SD. (D) Statistics of result in vitro, n = 6 (3 cell lineages x 2 replicates/group). Data are presented as mean +/− SD.