Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

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Volume 14, Issue 19

15 October, 2022
pp 7650—8139

About the Cover

The cover features Figure 3 "Comparison of DNAmage and chronological age obtained with the four epigenetic clocks" from Daunay et al.

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Research Papers

Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle

Lei Liu, Xianlin Yue, Zewei Sun, William S. Hambright, Qi Feng, Yan Cui, Johnny Huard, Paul D. Robbins, Zhihui Wang, Xiaodong Mu,

https://doi.org/10.18632/aging.204275 pp 7650—7661

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Lotus germ extract rejuvenates aging fibroblasts via restoration of disrupted proteostasis by the induction of autophagy

Kayo Machihara, Sou Kageyama, Shoma Oki, Hiroki Makino, Masamichi Sasaki, Hiroyasu Iwahashi, Takushi Namba,

https://doi.org/10.18632/aging.204303 pp 7662—7691

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Natural variation in macrophage polarization and function impact pneumocyte senescence and susceptibility to fibrosis

Eun Joo Chung, Seokjoo Kwon, Uma Shankavaram, Ayla O. White, Shaoli Das, Deborah E. Citrin,

https://doi.org/10.18632/aging.204309 pp 7692—7717

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Centenarians consistently present a younger epigenetic age than their chronological age with four epigenetic clocks based on a small number of CpG sites

Antoine Daunay, Lise M. Hardy, Yosra Bouyacoub, Mourad Sahbatou, Mathilde Touvier, Hélène Blanché, Jean-François Deleuze, Alexandre How-Kit,

https://doi.org/10.18632/aging.204316 pp 7718—7733

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Aging attenuates diurnal lipid uptake by brown adipose tissue

Wietse In het Panhuis, Milena Schönke, Ricky Siebeler, Salwa Afkir, Rianne Baelde, Amanda C.M. Pronk, Trea C.M. Streefland, Hetty C.M. Sips, Reshma A. Lalai, Patrick C.N. Rensen, Sander Kooijman,

https://doi.org/10.18632/aging.204318 pp 7734—7751

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Association between work characteristics and epigenetic age acceleration: cross-sectional results from UK – Understanding Society study

Anna Freni-Sterrantino, Giovanni Fiorito, Angelo d’Errico, Marianna Virtanen, Leena Ala-Mursula, Marjo-Riitta Järvelin, Paolo Vineis, Oliver Robinson,

https://doi.org/10.18632/aging.204327 pp 7752—7773

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DNA methylation-regulated YTHDF2 correlates with cell migration and immune cell infiltration in glioma

Xiulin Jiang, Xi Chen, Xiaobin Huang, Chunyan Wang, Chenyang Wang, Chenglong Pan, William C. Cho, Zhi Nie, Jun Pu, Weixiang Wang,

https://doi.org/10.18632/aging.204104 pp 7774—7793

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Multifaceted investigation underlies diverse mechanisms contributing to the downregulation of Hedgehog pathway-associated genes INTU and IFT88 in lung adenocarcinoma and uterine corpus endometrial carcinoma

Ho Yin Edwin Chan, Zhefan Stephen Chen,

https://doi.org/10.18632/aging.204262 pp 7794—7823

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DNA methylation regulator-mediated modification patterns and tumor microenvironment characterization in glioma

Haitao Luo, Minhua Ye, Yan Hu, Miaojing Wu, Mengqi Cheng, Xingen Zhu, Kai Huang,

https://doi.org/10.18632/aging.204291 pp 7824—7850

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Over-expression of NFYB affects stromal cells reprogramming and predicts worse survival in gastric cancer patients

Tailiang Lu, Chenglong Li, Cailing Xiang, Yongqiang Gong, Wei Peng, Futao Hou, Chaowu Chen,

https://doi.org/10.18632/aging.204294 pp 7851—7865

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Comprehensive analysis of DTYMK for estimating the immune microenvironment, diagnosis, prognosis effect in patients with lung adenocarcinoma

Xi Chen, Yixiao Yuan, Fan Zhou, Xiaobin Huang, Jun Pu, Xiaoqun Niu, Xiulin Jiang, Xiaoyan Ding,

https://doi.org/10.18632/aging.204308 pp 7866—7876

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Hyperlipidemia attenuates the mobilization of endothelial progenitor cells induced by acute myocardial ischemia via VEGF/eNOS/NO/MMP-9 pathway

Jidong Zhou, Hang Li, Liying Xun, Lei Wang, Qitao Zhao,

https://doi.org/10.18632/aging.204314 pp 7877—7889

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Comprehensive bioinformatics analysis of ribonucleoside diphosphate reductase subunit M2(RRM2) gene correlates with prognosis and tumor immunotherapy in pan-cancer

Liyuan Wu, Le Yin, Linxiang Ma, Jiarui Yang, Feiya Yang, Baofa Sun, Xing Nianzeng,

https://doi.org/10.18632/aging.204315 pp 7890—7905

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Pseudogene UBE2MP1 derived transcript enhances in vitro cell proliferation and apoptosis resistance of hepatocellular carcinoma cells through miR-145-5p/RGS3 axis

Fengjie Hao, Nan Wang, Honglian Gui, Yifan Zhang, Zhiyuan Wu, Junqing Wang,

https://doi.org/10.18632/aging.204319 pp 7906—7925

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Identification of ACSF gene family as therapeutic targets and immune-associated biomarkers in hepatocellular carcinoma

Zijin Zhao, Miaomiao Liu, Zhijie Xu, Yuan Cai, Bi Peng, Qiuju Liang, Yuanliang Yan, Wei Liu, Fanhua Kang, Qingchun He, Qianhui Hong, Wenqin Zhang, Jianbo Li, Jinwu Peng, Shuangshuang Zeng,

https://doi.org/10.18632/aging.204323 pp 7926—7940

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ERAP2 as a potential biomarker for predicting gemcitabine response in patients with pancreatic cancer

Pian Yu, Shifu Luo, Jiaxin Cai, Jie Li, Cong Peng,

https://doi.org/10.18632/aging.204324 pp 7941—7958

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APEX1 promotes the oncogenicity of hepatocellular carcinoma via regulation of MAP2K6

Zhipeng Sun, Guangyang Chen, Liang Wang, Qing Sang, Guangzhong Xu, Nengwei Zhang,

https://doi.org/10.18632/aging.204325 pp 7959—7971

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DAZAP1 facilitates the alternative splicing of KITLG to promote multiple myeloma cell proliferation via ERK signaling pathway

Yanyan Zhou, Shaohua Huangfu, Muxi Li, Chao Tang, Jinjun Qian, Mengjie Guo, Zuojian Zhou, Ye Yang, Chunyan Gu,

https://doi.org/10.18632/aging.204326 pp 7972—7985

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High FHL2 mRNA expression and its prognostic value in lung cancer

Yan Jiao, Junyuan Wei, Zhibin Li, Jintao Zhou, Yunpeng Liu,

https://doi.org/10.18632/aging.204328 pp 7986—8000

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Sex difference in the association between pathological albuminuria and subclinical atherosclerosis: insights from the I-Lan longitudinal aging study

Ya-Wen Lu, Chun-Chin Chang, Ruey-Hsing Chou, Yi-Lin Tsai, Li-Kuo Liu, Liang-Kung Chen, Po-Hsun Huang, Shing-Jong Lin,

https://doi.org/10.18632/aging.204331 pp 8001—8012

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Noncoding RNAs-mediated overexpression of KIF14 is associated with tumor immune infiltration and unfavorable prognosis in lung adenocarcinoma

Hong Wang, Fangting Tang, Ping Tang, Liang Zhang, Qixin Gan, Yuejun Li,

https://doi.org/10.18632/aging.204332 pp 8013—8031

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SENP3 affects the expression of PYCR1 to promote bladder cancer proliferation and EMT transformation by deSUMOylation of STAT3

Zhuo Li, Jian Liu, Huifeng Fu, Yuanwei Li, Qiang Liu, Wei Song, Mingqiang Zeng,

https://doi.org/10.18632/aging.204333 pp 8032—8045

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Palmitic acid inhibits vascular smooth muscle cell switch to synthetic phenotype via upregulation of miR-22 expression

Yanchao Hu, Yajie Fan, Chunyan Zhang, Congxia Wang,

https://doi.org/10.18632/aging.204334 pp 8046—8060

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Higher platelet count, even within normal range, is associated with increased arterial stiffness in young and middle-aged adults

Yu-Tsung Chou, Hung-Yu Chen, I-Hsuan Wu, Fei-Lin Su, Wen-Huang Li, Hung-Lung Hsu, Jui-Ting Tai, Ting-Hsing Chao,

https://doi.org/10.18632/aging.204335 pp 8061—8076

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Novel small molecular compound 2JY-OBZ4 alleviates AD pathology in cell models via regulating multiple targets

Qian Guo, Gang Wu, Fang Huang, Zhen Wei, Jian-Zhi Wang, Bin Zhang, Rong Liu, Yang Yang, Xiaochuan Wang, Hong-Lian Li,

https://doi.org/10.18632/aging.204336 pp 8077—8094

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Development and assessment of diabetic nephropathy prediction model using hub genes identified by weighted correlation network analysis

Xuelian Zhang, Yao Wang, Zhaojun Yang, Xiaoping Chen, Jinping Zhang, Xin Wang, Xian Jin, Lili Wu, Xiaoyan Xing, Wenying Yang, Bo Zhang,

https://doi.org/10.18632/aging.204340 pp 8095—8109

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Review

RNA modifications in aging-associated cardiovascular diseases

Xinyu Yang, Priyanka Gokulnath, H. Immo Lehmann, Zhitao Hou, Sun Yang, Liangzhen You, Guoxia Zhang, Yanwei Xing, Ji Lei, Guoping Li, Shuwen Guo, Hongcai Shang,

https://doi.org/10.18632/aging.204311 pp 8110—8136

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Corrections

Correction for: Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1α

Yan Huang, Fengbo Tan, Yi Zhuo, Jianyang Liu, Jialin He, Da Duan, Ming Lu, Zhiping Hu,

https://doi.org/10.18632/aging.204321 pp 8137—8138

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Correction for: The miR-590-3p/CFHR3/STAT3 signaling pathway promotes cell proliferation and metastasis in hepatocellular carcinoma

Zhongzhong Wan, Xingrun Li, Xinru Luo, Bofan Wang, Xiang Zhou, Ao Chen,

https://doi.org/10.18632/aging.204346 pp 8139

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