Research Paper Volume 14, Issue 19 pp 8032—8045
SENP3 affects the expression of PYCR1 to promote bladder cancer proliferation and EMT transformation by deSUMOylation of STAT3
Figure 7. The mechanism diagram of SENP3 promoting BC proliferation and invasion by upregulating STAT3. SENP3 induces deSUMOylation of STAT3, which promotes the phosphorylation of STAT3. Phosphorylation of STAT3 induces STAT3 translocating into nuclear. As a transcriptional factor, nuclear STAT3 promotes PYCR1 expression, resulting enhanced proliferation and invasion of BC.