Research Paper Volume 14, Issue 20 pp 8346—8356
Parthenolide targets NF-κB (P50) to inhibit HIF-1α-mediated metabolic reprogramming of HCC
Figure 2. Par inhibits the metastatic, invasive and glycolytic abilities of H22 cells. (A) IFA revealed high expression levels of P50 and HIF-1α in H22 cells, with strong fluorescence intensities. Par could suppress the P50 and HIF-1α expressions, as manifested by the significantly weakened fluorescence intensity in the Par group. (B, C) Protein assay demonstrated that Par inhibited the p-P50 and HIF-1α expressions in a dose-dependent manner. *P < 0.05 vs. DMSO group.