Research Paper Volume 14, Issue 20 pp 8346—8356
Parthenolide targets NF-κB (P50) to inhibit HIF-1α-mediated metabolic reprogramming of HCC
Figure 5. Par inhibits the tumor growth. (A) H&E staining revealed an impotent killing activity of Par against tumor tissues, without producing obvious tissue inflammation or evident toxic effect. (B–E) In the IHC staining and Western-Blot assays, Par inhibited the tissue expressions of P50 and HIF-1α in a dose-dependent manner. *P < 0.05 vs. Control group. (F) In the tumor mass detection, Par could inhibit the growth of tumor, significantly reducing the tumor mass. *P < 0.05 vs. Control group.