Research Paper Volume 14, Issue 20 pp 8346—8356
Parthenolide targets NF-κB (P50) to inhibit HIF-1α-mediated metabolic reprogramming of HCC
Figure 6. Targeted binding relationship between Par and P50. (A, B) According to the 3D and 2D images after Par–P50 binding, Par showed hydrogen bonding with THR, ARG and SER, and showed hydrophobic alkyl bonding with VAL and LEU. (C, D) Pull-down experiment revealed the presence of targeted binding between Par and P50, which agreed with the small molecule–protein docking results.