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Research Paper Volume 14, Issue 20 pp 8292—8301

α-Synuclein upregulates bim-mediated apoptosis by negatively regulating endogenous GCN5

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Figure 3. αS+/+ inhibiting endogenous GCN5 and inhibiting GCN5 expression. (A) co-immunoprecipitation of GCN5 in wildtype SH-SY5Y and probed for anti-αS. Endogenous protein expression of GCN5 in neuronal SH-SY5Y cells (B) and non-neuronal HEK293T cells (C) transfected (αS) or NC.