Research Paper Volume 14, Issue 20 pp 8568—8580
Identification and validation of genetic signature associated with aging in chronic obstructive pulmonary disease
Figure 1. DEGs associated with aging in COPD patients. (A) Volcano-plot of the 244 age-associated DEGs in COPD patients. Red circle: upregulated genes; blue circles: downregulated genes. (B) Top 10 GO biological processes analysis of the 244 age-associated DEGs. Outer gray circle: a scatter plot for each term of the logFC of the assigned genes; red circles: upregulated genes; blue circles: downregulated genes. (C) All GO cellular components analysis of the 244 age-associated DEGs. (D) Top 11 GO molecular functions analysis of the 244 age-associated DEGs. (E) Top 7 significantly (P<0.05) enriched KEGG pathways. DEGs, differently expressed genes; COPD, chronic obstructive pulmonary disease; GO, gene ontology; FC, fold change; KEGG, Kyoto Encyclopedia of Genes and Genomes.