Research Paper Volume 14, Issue 21 pp 8661—8687

Figure 6. Gene expression rewiring promotes dopaminergic neuron survival during aging. (A) Representative images of the head region of PD animals at day 6 adulthood in control and krill oil treated animals following knockdown of jnk-1, skn-1, hmg-5 and lmd-3 by RNAi, Scale bar, 20 μm. Time series plot for same genes are show on top. The scatter dot plots represent GFP intensity of the CEPs dopaminergic neurons in day 6 PD nematodes following knockdown of jnk-1, skn-1, hmg-5 and lmd-3 (n = 20 individuals; Error bars, s.e.m; ^***p < 0.001; one-way ANOVA followed by Bonferroni’s multiple comparison test). (B) representative images and scatter dot plots represents intensity of the dopaminergic neurons after depleting cnnm-3, pbo-2 and rim-1 in PD animals (n = 14 individuals, Scale bar, 20 μm Error bars, s.e.m; ^***p < 0.001; one-way ANOVA followed by Bonferroni’s multiple comparison test), co-related with time series plot for same genes.