Research Paper Volume 14, Issue 21 pp 8688—8699

Efficacy of zinc carnosine in the treatment of colorectal cancer and its potential in combination with immunotherapy in vivo

Figure 5. ZnC reduced tumor growth and increased the efficiency of anti-PD1 monoclonal antibody in xenograft mice model. (A) Procedures for establishing subcutaneously tumor-bearing mice model. PD1 antibody was injected internationally every 3 days. The mice injected with PBS were as the control. (B) Picture display of the respective group (PBS, ZnC, anti-PD1, and anti-PD1+ZnC) of subcutaneous tumors. (C, D) The volume (C) and weight (D) statistics of subcutaneous tumors in the respective group. (E) Immunohistochemical results of Ki67, PD-L1, and CD8 expression in the respective group. **p < 0.01, ***P < 0.001,****p < 0.0001.