Research Paper Volume 14, Issue 23 pp 9466—9483
Identification of natural products and FDA-approved drugs for targeting cancer stem cell (CSC) propagation
Figure 1. Dietary supplements decrease CSC propagation. The effects of two dietary supplements, quercetin and glucosamine hydrochloride, are shown. (A) Note that quercetin is effective in inhibiting CSC propagation, at a concentration of 40 μM and its IC50 falls in the range of 20 and 40 μM concentration. (B) Note that glucosamine significantly decreases mammosphere number, at concentrations of 5, 10 and 20 mM. Bar graphs are shown as the mean ± SEM; t-test, two-tailed test. ***p < 0.001, ****p < 0.0001. Chemical formulae are indicated.