Research Paper Volume 14, Issue 23 pp 9466—9483

Figure 11. Summary: Identification of natural products and FDA-approved drugs for targeting cancer stem cell (CSC) propagation. This scheme summarizes our current results related to quercetin, glucosamine hydrochloride and carvedilol compounds and their effects on i) CSC propagation and ii) energy metabolism in MCF7 cells. Quercetin is flavonoid found in many foods, glucosamine is a dietary supplement, and carvedilol is an FDA-approved beta-blocker. Intriguingly, although these three compounds are so different in their chemical structure, they share the ability to interfere with mitochondrial metabolism and block the propagation of CSCs.