Research Paper Volume 14, Issue 23 pp 9466—9483
Identification of natural products and FDA-approved drugs for targeting cancer stem cell (CSC) propagation
Figure 6. Flavours, citral and limonene, decrease mammosphere formation. Next, we tested the effects of two flavours, such as citral and limonene. (A) Citral or lemonal is effective in inhibiting CSC propagation, starting at the concentration of 10 μM, with an IC50 near 50 μM. (B) Limonene is a flavouring that significantly decreases the mammosphere formation, but was less effective than the closely related molecule, Citral. Bar graphs are shown as the mean ± SEM; t-test, two-tailed test. *p < 0.05, ***p < 0.001, ****p < 0.0001. Chemical formulae are indicated.