Research Paper Volume 14, Issue 23 pp 9699—9714
Establishing a signature based on immunogenic cell death-related gene pairs to predict immunotherapy and survival outcomes of patients with hepatocellular carcinoma
Figure 2. Construction and verification of ICD-related prognostic gene signature. (A) Forest plots showing the results of the Cox univariate regression of 15 ICD-related prognostic gene pairs. (B) The LASSO coefficient profile of 8 ICD-related prognostic gene pairs. (C) Selection of optimal LASSO model parameters for HCC patients (λ). (D, E) Kaplan-Meier survival curves of patients in low- and high-risk groups in training (D) and validation (E) sets. (F, G) The AUC values of the signature in the training (F) and validation sets (G). (H, I) C-index of the risk score and other clinical traits in the training (H) and validation sets (I). (J, K) Risk score and OS distributions were assessed in the training (J) and validation sets (K).