Research Paper Volume 14, Issue 23 pp 9393—9422
Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence
Figure 4. mRNA translation, gamma interferon and complement cascade are upregulated in selective cell types with aging. Pathway analysis of top 100 up-regulated and top 100 down-regulated genes with age in each cell type. GO, KEGG, Reactome pathways were queried. Over-representation was assessed using a hyper-geometric test at FDR 1%. (A) Upregulated with age. (B) Downregulated with age.