Research Paper Volume 15, Issue 1 pp 119—133

Profiling of a novel circadian clock-related prognostic signature and its role in immune function and response to molecular targeted therapy in pancreatic cancer

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Figure 6. Association of the gene signature with response to molecular targeted therapy in pancreatic ductal adenocarcinoma. (A) IC50 of BMS-536924, Erlotinib, Foretinib, Linsitinib, and Sabutoclax exhibited a distinct effect on the low- and the high-risk cohorts. (B) Quantitative analysis showed that BMS-536924, Foretinib, Linsitinib, and Sabutoclax were more sensitive in the low-risk cancer cells, whereas Erlotinib was more effective in the high-risk cancer cells.