Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

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Volume 15, Issue 1

15 January, 2023
pp 1—289

About the Cover

The cover features Figure 1 "t-SNE visualization of 14,588 old and young peripheral blood cells" from Teo et al.

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Editorials

The complex determinants of Alzheimer’s-type dementias

Bruce M. Cohen, Kai-Christian Sonntag,

https://doi.org/10.18632/aging.204478 pp 1—3

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Applications of Alzheimer’s disease staging to clinical trials

Joseph Therriault, Serge Gauthier, Pedro Rosa-Neto,

https://doi.org/10.18632/aging.204482 pp 4—5

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Research Papers

Single-cell transcriptomics of peripheral blood in the aging mouse

Yee Voan Teo, Samuel J. Hinthorn, Ashley E. Webb, Nicola Neretti,

https://doi.org/10.18632/aging.204471 pp 6—20

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The innate immune signaling component FBXC-58 mediates dietary restriction effects on healthy aging in Caenorhabditis elegans

Jeong-Hoon Hahm, Farida S. Nirmala, Pyeong Geun Choi, Hyo-Deok Seo, Tae Youl Ha, Chang Hwa Jung, Jiyun Ahn,

https://doi.org/10.18632/aging.204477 pp 21—36

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Genetic deficiency and pharmacological modulation of RORα regulate laser-induced choroidal neovascularization

Chi-Hsiu Liu, Felix Yemanyi, Kiran Bora, Neetu Kushwah, Alexandra K. Blomfield, Theodore M. Kamenecka, John Paul SanGiovanni, Ye Sun, Laura A. Solt, Jing Chen,

https://doi.org/10.18632/aging.204480 pp 37—52

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miR-6742-5p regulates the invasion and migration of lung adenocarcinoma cells via mediating FGF8/ERK12/MMP9/MMP2 signaling pathway

Minglei Song, Xiaoying Xing,

https://doi.org/10.18632/aging.204277 pp 53—69

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Histone methyltransferase Smyd2 drives vascular aging by its enhancer-dependent activity

Zhenghua Su, Haibi Su, Jie Xu, Gang Wei, Lefeng Qu, Ting Ni, Di Yang, Yizhun Zhu,

https://doi.org/10.18632/aging.204449 pp 70—91

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Comprehensive bioinformatics analysis reveals the significance of forkhead box family members in pancreatic adenocarcinoma

Wei Hu, Mingxu Li, Yan Wang, Chengcheng Zhong, Xinxin Si, Xiao Shi, Zhong Wang,

https://doi.org/10.18632/aging.204455 pp 92—107

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Association between Apolipoprotein E genotype and functional outcome in acute ischemic stroke

Xiaoming Rong, Jingjuan Chen, Dong Pan, YuKai Wang, Chengguo Zhang, Yamei Tang,

https://doi.org/10.18632/aging.204460 pp 108—118

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Profiling of a novel circadian clock-related prognostic signature and its role in immune function and response to molecular targeted therapy in pancreatic cancer

Yu Jin, Shuang Gong, Guochen Shang, Lilin Hu, Gangping Li,

https://doi.org/10.18632/aging.204462 pp 119—133

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A case-control study coupling with meta-analysis elaborates decisive association between IGF-1 rs35767 and osteoporosis in Asian postmenopausal females

Sui-Lung Su, Yung-Hsun Huang, Yu-Hsuan Chen, Pi-Shao Ko, Wen Su, Chih-Chien Wang, Meng-Chang Lee,

https://doi.org/10.18632/aging.204464 pp 134—147

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Investigation on the mechanism of Shaoyao-Gancao Decoction in the treatment of gastric carcinoma based on network pharmacology and experimental verification

Xin Zhou, Jiao Min, Mengying Che, Yating Yang, Yi Yang, Junfei Zhang, Lei Zhang, Xiaosha Zheng, Yan Chen, Ling Yuan, Yi Nan,

https://doi.org/10.18632/aging.204465 pp 148—163

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Doxorubicin induced ROS-dependent HIF1α activation mediates blockage of IGF1R survival signaling by IGFBP3 promotes cardiac apoptosis

Su-Ying Wen, Ayaz Ali, I-Chieh Huang, Jian-Sheng Liu, Po-Yuan Chen, Vijaya Padma Viswanadha, Chih-Yang Huang, Wei-Wen Kuo,

https://doi.org/10.18632/aging.204466 pp 164—178

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lncRNA HCG11 suppresses cell proliferation in hormone receptor-positive breast cancer via SRSF1/β-catenin

Dan Xie, Saiyang Li, Xuehui Wang, Lin Fang,

https://doi.org/10.18632/aging.204468 pp 179—192

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A two-gene random forest model to diagnose osteoarthritis based on RNA-binding protein-related genes in knee cartilage tissue

Wenhua Yin, Ying Lei, Xuan Yang, Jiawei Zou,

https://doi.org/10.18632/aging.204469 pp 193—212

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Immune infiltration and immunophenotyping in atrial fibrillation

Yuqing Tian, Shiying Liu, Yanan Zhang, Jiefu Yang, Peiyao Guo, Hongchao Zhang, Xue Yu, Tong Zou,

https://doi.org/10.18632/aging.204470 pp 213—229

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Increased expression of GPX4 promotes the tumorigenesis of thyroid cancer by inhibiting ferroptosis and predicts poor clinical outcomes

Huanjie Chen, Fang Peng, Jingchao Xu, Guangzhi Wang, Yongfu Zhao,

https://doi.org/10.18632/aging.204473 pp 230—245

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Mitoquinone shifts energy metabolism to reduce ROS-induced oxeiptosis in female granulosa cells and mouse oocytes

Kuan-Hao Tsui, Chia-Jung Li,

https://doi.org/10.18632/aging.204475 pp 246—260

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The protective effect of luteolin on the depression-related dry eye disorder through Sirt1/NF-κB/NLRP3 pathway

Mingxia Xie, Hanqing Wang, Tiantian Gao, Jun Peng, Pan Meng, Xi Zhang, Dongwei Guo, Guangya Liu, Jian Shi, Qinghua Peng,

https://doi.org/10.18632/aging.204479 pp 261—275

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Effects of NBP on postoperative cognitive dysfunction in rats via Nrf 2/ARE pathway

Jianshuai He, Junqiong Gao, He Zhu, Yang Zhao, Xiaotian Zhang, Xiufang Wang, Shengnan Wan, Hongying Cao, Lin Zhai, Yuanyong Wang, Shilei Wang,

https://doi.org/10.18632/aging.204481 pp 276—286

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Corrections

Correction for: Endothelin-1-mediated miR-let-7g-5p triggers interlukin-6 and TNF-α to cause myopathy and chronic adipose inflammation in elderly patients with diabetes mellitus

Chung-Huang Tsai, Pei-Ju Huang, IT Lee, Chien-Min Chen, Min Huan Wu,

https://doi.org/10.18632/aging.204488 pp 287

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Correction for: Ganglioside GD1a enhances osteogenesis by activating ERK1/2 in mesenchymal stem cells of Lmna mutant mice

Dong Hoon Kwak, Ji Hye Park, Eul Sig Choi, Seong Hyun Park, Seo-Yeon Lee, Seoul Lee,

https://doi.org/10.18632/aging.204489 pp 288—289

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