Research Paper Volume 15, Issue 1 pp 261—275
The protective effect of luteolin on the depression-related dry eye disorder through Sirt1/NF-κB/NLRP3 pathway
Figure 1. Luteolin improved depressive behavior and dry eye symptoms in DEDC mice. (A, B) SPT, (C) TST, (D) FST, and (E, F) OFT. (G) Corneal epithelial defect fluorescence representative images of pyruvate sodium staining (H) Quantitative determination of corneal defects in mice (I, J) Phenol red line assay showing tear volume (K) The effect of luteolin on goblet cells in xerophthalmia and CUMS mice. Scale bar is 50 μm. Data analysis was performed with Mean ± SEM. #p < 0.05, ##p < 0.01 compared with blank group; *p < 0.05, **p < 0.01 compared with model group, n = 9.