Research Paper Volume 15, Issue 3 pp 601—616
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
Figure 2. Age acceleration between metformin users and nonusers. Age acceleration was calculated using the Horvath epigenetic clock as DNAm age - chronological age. Metformin = 0: without history of metformin use, Metformin = 1: with history of metformin use. p = 0.34.