Research Paper Volume 15, Issue 3 pp 734—747
MiR-181a-5p promotes osteogenesis by targeting BMP3
Figure 5. Inhibition of miR-181a-5p aggravated senile osteoporosis in mice. (A) Representative 3D reconstruction images of microarchitecture in the mice tibia. Groups are divided as follows: 6-month-old mice, 18-month-old mice, 18-month-old mice treated with antagomir-negative control (NC) and 18-month-old mice treated with antagomir-miR-181a-5p. (B–G) Micro-CT analysis includes trabecular thickness (Tb.Th), trabecular number (Tb.N), trabecular separation (Tb.Sp), trabecular pattern factor (Tb.Pf), bone volume fraction (BV/TV) and bone surface density (BS/TV). All data represent mean ± s.e.m. (n = 5). *P<0.05 compared with the 6-month-old mice group. #P<0.05 compared with the group of 18-month-old mice treated with antagomir-NC.