Research Paper Volume 15, Issue 6 pp 1931—1943
Exosomal miR-370-3p increases the permeability of blood-brain barrier in ischemia/reperfusion stroke of brain by targeting MPK1
Figure 1. Expression of miR-370-3p in the cerebral I/R rats. (A) Experimental design to measure BBB leakage in cerebral I/R rats (n=10). (B) Infarct volume was assessed using 2,3,5-triphenyltetrazolium chloride (TTC) staining. (C) BBB permeability was evaluated by Evan’s blue assay. (D) The top 5 most highly expressed mRNAs in I/R rats based on RNA sequencing data. (E) The relative expressions of miR-370-3p in the cerebral I/R rats were determined by qPCR. (F) miR-370-3p levels were assessed by immunofluorescent staining. (G) Correlation between miR-370-3p and infraction volume. (H) Correlation between miR-370-3p and BBB permeability. ** p<0.01, *** p<0.005, **** p<0.001.