Research Paper Volume 15, Issue 6 pp 2158—2169
Reduction of NgR in perforant path protects neuronal morphology and function in APP/PS1 transgenic mice
Figure 2. NgR reduction alleviates neuronal apoptosis in APP/PS1 transgenic mice. (A) The images are Nissl staining of TG-vector mice and TG-shNgR mice. The arrow points to neurons stained dark with karyopyknosis and blurred Nissl bodies. (B) Quantitative analysis of Nissl staining integrated densities in the hippocampus. (C) Neuronal apoptosis in the hippocampus was determined using TUNEL-NeuN double staining in APP/PS1 transgenic mice. (D) Quantitative analysis of TUNEL positive neurons in the hippocampus. Data are presented as mean ± SEM. n = 3-5 male mice/group. The statistical analysis was performed by Student’s t test. *P < 0.05; **P < 0.01.