Research Paper Volume 15, Issue 6 pp 2158—2169
Reduction of NgR in perforant path protects neuronal morphology and function in APP/PS1 transgenic mice
Figure 3. NgR improves dendritic growth and complexity of neuron in APP/PS1 transgenic mice. (A) Representative image of neurons in the hippocampus, and concentric rings for Sholl analysis. (B) Quantification of dendritic complexity by Sholl analysis. (C) Representative images of dendrite showing complex neuron processes. (D) Analysis of the total dendritic length from TG-shNgR mice and TG-vector mice. (E) Analysis of the number of branch points from TG-shNgR mice and TG-vector mice. Data are presented as mean ± SEM. n = 3-5 male mice/group. The statistical analysis was performed by Student’s t test. *P < 0.05; ***P < 0.001.