Research Paper Volume 15, Issue 6 pp 2158—2169
Reduction of NgR in perforant path protects neuronal morphology and function in APP/PS1 transgenic mice
Figure 4. NgR decreased the postsynaptic density, but did not affect the presynaptic expression in the hippocampus of APP/PS1 transgenic mice. (A) The neuronal synapses were observed under electron microscope in hippocampus of TG-vector mice and TG-shNgR mice. The arrow points to postsynaptic dense bodies. (B–E) Representative micrographs of Western blot and densitometry analysis of PSD95, synaptophysin and synapsin I in the hippocampus. Data are presented as mean ± SEM. n = 3-5 male mice/group. The statistical analysis was performed by Student’s t test. *P < 0.05; **P < 0.01.