Research Paper Volume 15, Issue 6 pp 2189—2207

Figure 4. The results of the animal experiment based on African elephant TP53 transgenic SKOV3 cells. The q-PCR analysis showed the mRNA expression levels of TP53 in SKOV3 cell after the transfection of lentivirus (A). After 18 days of treatment, the mice were euthanized for analysis of tumors. The images of harvested tumors (B). Tumor weights are shown as means ± SD (C). n =7-8, **p < 0.01. Tumor growth curve during intervention (D). The points and bars represent means ± SD. n =7-8, **p < 0.01, ***p < 0.001, ****p < 0.0001. Body weight changes of mice during intervention (E). Representative images of xenograft of each group in fluorescence confocal (F). Nuclei were stained with DAPI (blue). Bars =100 μm.