Research Paper Volume 15, Issue 6 pp 2347—2357
MiR-320b aberrant expression enhances the radioresistance of human glioma via upregulated expression of ALDH1A3
Figure 5. Low expression of miR-320b is associated with poor outcomes and radioresistance in glioma. (A) miR-320b in different WHO grades of glioma based on the CGGA database. (B) Kaplan-Meier analysis of the CGGA database showed a longer overall survival of glioma patients with elevated miR-320b levels. (C) miR-320b was enriched in adjacent normal tissues compared with glioma tissues. (D) Decreased expression of miR-320b was observed in GBM cell lines compared to human cortical neurons (HCN2). (E and F) The mRNA expression levels of miR-320b when GBM cells were exposed to different doses of irradiation (0 Gy, 2 Gy, 4 Gy and 6 Gy). *p < 0.05, **p < 0.01.