Research Paper Volume 15, Issue 7 pp 2582—2609

Figure 3. Mutation landscape of AIF-1 in pan-cancer. (A) The AIF-1 alteration frequency and mutation type in various cancers were displayed. (B) The entire mutation count of AIF-1 from the TCGA dataset is based on the cBioPortal tool. (C) Waterfall plot showing the cooccurrence pattern of AIF-1 alteration with genetic alterations of HSPA1L, PRRC2A, C2, MICB, SLC44A4, MSH5, VWA7, C4A, LTA, and NELFE. (D) Bar plot showing the frequencies of IGHV1-58, TRBV3-1, KRT19P2, SOCS2-AS1, CRADD-AS1, FAM170B-AS1, TRBV6-7, C10ORF71-AS1, ERCC6-PGBD3, and FAM21EP alteration cooccurrence with AIF-1 alteration. (E) Mutation sites are displayed in the AIF-1 structural domain. (F) The highest alteration frequency (G136C/P138Qfs*36) was displayed in the 3D structure of AIF-1 (labeled in yellow). (G) The potential correlation between AIF-1 mutation status and overall, disease-specific, disease-free, and progression-free survival. The original description lacked a comma between overall and disease specific survival.