Research Paper Volume 15, Issue 7 pp 2418—2432
Effect of deferoxamine and ferrostatin-1 on salivary gland dysfunction in ovariectomized rats
Figure 7. Schematic diagram of postmenopausal salivary gland dysfunction in ovariectomized rats. After menopause, iron and lipids accumulate in the salivary glands and GPX4 activity decreases. This promotes lipid peroxidation and induces ferroptosis. DFO and FER inhibit the ferroptosis pathway, thus reducing salivary gland dysfunction.