Research Paper Volume 15, Issue 7 pp 2705—2720
Berberine mitigates intracerebral hemorrhage-induced neuroinflammation in a gut microbiota-dependent manner in mice
Figure 2. Effect of berberine on gut permeability and gut intestinal integrity after ICH. (A) The representative image of immunofluorescence staining of the tight junction protein Claudin-1 in ICH + Vehicle and ICH + Ber at day 3. (n = 5 per group). (B) The mean of densities of Claudin-1 after ICH day 3. (C) Ber treatment improved the intestinal permeability after ICH day 3. (n = 5 per group). (D) The level of LBP in plasma after Ber treatment day 3 in ICH mice. (n = 5 per group). Data are expressed as the mean ± SEM. #P < 0.05. ##P < 0.01. ###P < 0.001 sham vs. ICH + Vehicle group. *P < 0.05. **P < 0.01. ***P < 0.001 ICH + Vehicle group vs. ICH + Ber group. Scale bar = 200 μm.