Research Paper Volume 15, Issue 7 pp 2705—2720
Berberine mitigates intracerebral hemorrhage-induced neuroinflammation in a gut microbiota-dependent manner in mice
Figure 6. Transplantation of fecal microbiome from Ber treatment ICH mice improves the gut function. (A) The representative image of immunofluorescence staining of the tight junction protein Claudin-1 in ICH + FMT (Vehicle) and ICH + FMT (Ber) at day 3. (B) The mean of densities of Claudin-1 after ICH day 3. (n = 5 per group). (C) FMT treatment improved the intestinal permeability after ICH day 3. (n = 5 per group). (D) The level of LBP in plasma after FMT treatment after ICH day 3. (n = 5 per group). Data are expressed as the mean ± SEM. #P < 0.05. ##P < 0.01. ###P < 0.001 sham vs. ICH + FMT (Vehicle) group. *P < 0.05. **P < 0.01. ***P < 0.001 ICH + FMT (Vehicle) vs. ICH + FMT (Ber) group. Scale bar = 200 μm.