Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring

Giovanni Vitale; Michael P Brugts; Giulia Ogliari; Davide Castaldi; Letizia M. Fatti; Aimee J. Varewijck; Steven W. Lamberts; Daniela Monti; Laura Bucci; Elisa Cevenini; Francesco Cavagnini; Claudio Franceschi; Leo J Hofland; Daniela Mari; Joseph A.M.J.L. Janssen

doi:doi:10.18632/aging.100484

Research Paper Volume 4, Issue 9 pp 580—589

Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring

Giovanni Vitale^1,2,, Michael P Brugts^3,, Giulia Ogliari^1,4,, Davide Castaldi^2,5,, Letizia M. Fatti^2,, Aimee J. Varewijck^3,, Steven W. Lamberts^3,, Daniela Monti^6,, Laura Bucci^7,, Elisa Cevenini^7,, Francesco Cavagnini^2,, Claudio Franceschi^7,8,, Leo J Hofland^3,, Daniela Mari^1,4,, Joseph A.M.J.L. Janssen^3,,

¹ Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
² IRCCS Istituto Auxologico Italiano, Milan, Italy
³ Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
⁴ Geriatric Unit IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy
⁵ Dipartimento di Informatica, Sistemistica e Comunicazione, Universita' degli Studi di Milano Bicocca, Milan, Italy
⁶ Department of Experimental Pathology and Oncology, University of Florence, Florence, Italy
⁷ C.I.G. Interdepartmental Center “L. Galvani”, University of Bologna, Bologna, Italy
⁸ Department of Experimental Pathology, University of Bologna, Bologna, Italy

Received: June 28, 2012 Accepted: September 8, 2012 Published: September 9, 2012

https://doi.org/10.18632/aging.100484
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Vitale G, Brugts MP, Ogliari G, Castaldi D, Fatti LM, Varewijck AJ, Lamberts SW, Monti D, Bucci L, Cevenini E, Cavagnini F, Franceschi C, Hofland LJ, et al, . Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring. Aging (Albany NY). 2012; 4:580-589. https://doi.org/10.18632/aging.100484

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Provider: 
        TY  - JOUR
        AU  - Vitale, Giovanni 
        AU  - Brugts, Michael P 
        AU  - Ogliari, Giulia 
        AU  - Castaldi, Davide 
        AU  - Fatti, Letizia M. 
        AU  - Varewijck, Aimee J. 
        AU  - Lamberts, Steven W. 
        AU  - Monti, Daniela 
        AU  - Bucci, Laura 
        AU  - Cevenini, Elisa 
        AU  - Cavagnini, Francesco 
        AU  - Franceschi, Claudio 
        AU  - Hofland, Leo J 
        AU  - Mari, Daniela 
        AU  - Janssen, Joseph A.M.J.L. 
        TI  - Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring
        JO  - 
        JA  - Aging (Albany NY)
        VL  - 4
        IS  - 9
        PB  - 
        SN  - 
        UR  - https://doi.org/10.18632/aging.100484
        DO  - 10.18632/aging.100484
        SP  - 580
        EP  - 589
        PY  - 
        AB  - Centenarians’ offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovative IGF-I Kinase Receptor Activation (KIRA) Assay, total IGF-I, IGFBP-3, total IGF-II, insulin, glucose, HOMA2-B% and HOMA2-S% in 192 centenarians’ offspring and 80 offspring-controls of which both parents died relatively young. Both groups were well-matched for age, gender and BMI with the centenarians’ offspring. IGF-I bioactivity (p&lt;0.01), total IGF-I (p&lt;0.01) and the IGF-I/IGFBP-3 molar ratio (p&lt;0.001) were significantly lower in centenarians’ offspring compared to offspring matched-controls. Serum insulin, glucose, HOMA2-B% and HOMA2-S% values were similar between both groups. In centenarians’ offspring IGF-I bioactivity was inversely associated to insulin sensitivity. In conclusion: 1) centenarians’ offspring had relatively lower circulating IGF-I bioactivity compared to offspring matched-controls; 2) IGF-I bioactivity in centenarians’ offspring was inversely related to insulin sensitivity. These data support a role of the IGF-I/insulin system in the modulation of human aging process.
        ER  -

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Abstract

Centenarians’ offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovative IGF-I Kinase Receptor Activation (KIRA) Assay, total IGF-I, IGFBP-3, total IGF-II, insulin, glucose, HOMA2-B% and HOMA2-S% in 192 centenarians’ offspring and 80 offspring-controls of which both parents died relatively young. Both groups were well-matched for age, gender and BMI with the centenarians’ offspring. IGF-I bioactivity (p<0.01), total IGF-I (p<0.01) and the IGF-I/IGFBP-3 molar ratio (p<0.001) were significantly lower in centenarians’ offspring compared to offspring matched-controls. Serum insulin, glucose, HOMA2-B% and HOMA2-S% values were similar between both groups. In centenarians’ offspring IGF-I bioactivity was inversely associated to insulin sensitivity. In conclusion: 1) centenarians’ offspring had relatively lower circulating IGF-I bioactivity compared to offspring matched-controls; 2) IGF-I bioactivity in centenarians’ offspring was inversely related to insulin sensitivity. These data support a role of the IGF-I/insulin system in the modulation of human aging process.

Research Paper Volume 4, Issue 9 pp 580—589

Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring

Received: June 28, 2012 Accepted: September 8, 2012 Published: September 9, 2012

Abstract

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