Advance | Aging

A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training

Michael D. Roberts, Bradley A. Ruple, Joshua S. Godwin, Mason C. McIntosh, Shao-Yung Chen, Nicholas J. Kontos, Anthony Agyin-Birikorang, Max Michel, Daniel L. Plotkin, Madison L. Mattingly, Brooks Mobley, Tim N. Ziegenfuss, Andrew D. Fruge, Andreas N. Kavazis,

https://doi.org/10.18632/aging.205751

View Abstract PDF Full-Text How to Cite

Associations among NMR-measured inflammatory and metabolic biomarkers and accelerated aging in cardiac catheterization patients

Henry Raab, Elizabeth R. Hauser, Lydia Coulter Kwee, Svati H. Shah, William E. Kraus, Cavin K. Ward-Caviness,

https://doi.org/10.18632/aging.205758

View Abstract PDF Full-Text How to Cite

The association between neighborhood deprivation and DNA methylation in an autopsy cohort

Lindsay Pett, Zhenjiang Li, Sarina Abrishamcar, Kenyaita Hodge, Todd Everson, Grace Christensen, Marla Gearing, Michael S. Kobor, Chaini Konwar, Julia L. MacIsaac, Kristy Dever, Aliza P. Wingo, Allan Levey, James J. Lah, Thomas S. Wingo, Anke Hüls,

https://doi.org/10.18632/aging.205764

View Abstract PDF Full-Text How to Cite

Characterization of age-associated gene expression changes in mouse sweat glands

Alexandra G. Zonnefeld, Chang-Yi Cui, Dimitrios Tsitsipatis, Yulan Piao, Jinshui Fan, Krystyna Mazan-Mamczarz, Yutong Xue, Fred E. Indig, Supriyo De, Myriam Gorospe,

https://doi.org/10.18632/aging.205776

View Abstract PDF Full-Text How to Cite

Electroacupuncture alleviates the symptom of depression in mice by regulating the cGAS-STING-NLRP3 signaling

Shiyun Chen, Jingjing Li, Luda Yan, Xianhao Zhang, Jiesi Huang, Peng Zhou,

https://doi.org/10.18632/aging.205596

View Abstract PDF Full-Text How to Cite

Exploring the anti-atherosclerosis mechanism of ginsenoside Rb1 by integrating network pharmacology and experimental verification

Lianjie Hou, Zhiming Zou, Yu Wang, Hui Pi, Zeyue Yuan, Qin He, Yongfang Kuang, Guojun Zhao,

https://doi.org/10.18632/aging.205680

View Abstract PDF Full-Text How to Cite

USP15 facilitates the progression of bladder cancer by amplifying the activation of the NF-κB signaling pathway

Yun Li, Chenghang Jiang, Quanqi Liu, Pengfei Zhou, Daxue Tian, Ying Zeng, Mingfeng Xiang,

https://doi.org/10.18632/aging.205696

View Abstract PDF Full-Text How to Cite

Establishment and verification of a prognostic model based on coagulation and fibrinolysis-related genes in hepatocellular carcinoma

Meng Fan, Le Lu, Hao Shang, Yuxuan Lu, Yi Yang, Xiuyan Wang, Hongwei Lu,

https://doi.org/10.18632/aging.205699

View Abstract PDF Full-Text How to Cite

CCNA2 and KIF23 are molecular targets for the prognosis of adenoid cystic carcinoma

Yongbin Di, Haolei Zhang, Bohao Zhang, Tianke Li, Dan Li,

https://doi.org/10.18632/aging.205703

View Abstract PDF Full-Text How to Cite

An LRPPRC-HAPSTR1-PSMD14 interaction regulates tumor progression in ovarian cancer

Dongxiao Li, Min Wang,

https://doi.org/10.18632/aging.205713

View Abstract PDF Full-Text How to Cite

Clinical characteristics and prognostic analysis of primary extranodal non-Hodgkin lymphoma of the head and neck

Jiamu Lv, Yining Jiang, Tingting Yu, Shengrui Gao, Wanzhong Yin,

https://doi.org/10.18632/aging.205726

View Abstract PDF Full-Text How to Cite

Comprehensive analysis of macrophage-related genes in prostate cancer by integrated analysis of single-cell and bulk RNA sequencing

Jili Zhang, Zhihao Li, Zhenlin Chen, Wenzhen Shi, Yue Xu, Zhangcheng Huang, Zequn Lin, Ruiling Dou, Shaoshan Lin, Xin Jiang, Mengqiang Li, Shaoqin Jiang,

https://doi.org/10.18632/aging.205727

View Abstract PDF Full-Text How to Cite

Age and aging process alter the gut microbes

Qu Zhanbo, Zhuang Jing, Han Shugao, Wu Yinhang, Chu Jian, Yu Xiang, Zhao Feimin, Liu Jian, Wu Xinyue, Wu Wei, Han Shuwen,

https://doi.org/10.18632/aging.205728

View Abstract PDF Full-Text How to Cite

ITGAM is a critical gene in ischemic stroke

Lei Hou, Zhongchen Li, Xiaoli Guo, Jiatao Lv, Zonglei Chong, Yilei Xiao, Liyong Zhang, Zefu Li,

https://doi.org/10.18632/aging.205729

View Abstract PDF Full-Text How to Cite

lincRNA00907 promotes NASH progression by targeting miRNA-942-5p/TAOK1

Gang Du, Zhaochen Jiang, Tong Xia, Mingkun Liu, Zeyang Liu, Huaxin Zhou, Hao Zhang, Xiangyu Zhai, Bin Jin,

https://doi.org/10.18632/aging.205730

View Abstract PDF Full-Text How to Cite

PROS1 is a crucial gene in the macrophage efferocytosis of diabetic foot ulcers: a concerted analytical approach through the prisms of computer analysis

Hongshuo Shi, Zhicheng Zhang, Xin Yuan, Guobin Liu, Weijing Fan, Wenbo Wang,

https://doi.org/10.18632/aging.205732

View Abstract PDF Full-Text How to Cite

Tertiary lymphoid structures associated with enhanced anti-tumor immunity and favorable prognosis in cervical squamous carcinoma

Guohai Xiong, Jinmei Shan, Qingguo Chong, Yueqing Cui,

https://doi.org/10.18632/aging.205733

View Abstract PDF Full-Text How to Cite

Compound sophora decoction alleviates ulcerative colitis by regulating macrophage polarization through cGAS inhibition: network pharmacology and experimental validation

Fei Gao, Shuangjiao Deng, Yujin Liu, Pengcheng Wu, Lifen Huang, Feng Zhu, Chunzhu Wei, Yuyi Yuan, Yang Gui, Yushi Tian, Heng Fan, Hui Wu,

https://doi.org/10.18632/aging.205734

View Abstract PDF Full-Text How to Cite

High-dose Vitamin C injection ameliorates against sepsis induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NF-κB and PI3K/AKT/mTOR signaling pathways in rats

Ya-Nan Cui, Na Tian, Yan-Hai Luo, Ji-Jun Zhao, Cheng-Fei Bi, Yi Gou, Jia Liu, Ke Feng, Jun-Fei Zhang,

https://doi.org/10.18632/aging.205735

View Abstract PDF Full-Text How to Cite

Identification of a robust biomarker LAPTM4A for glioma based on comprehensive computational biology and experimental verification

Yongqi Ding, Yike Jiang, Hong Zeng, Minqin Zhou, Xuanrui Zhou, Zichuan Yu, Jingying Pan, Xitong Geng, Yanting Zhu, Hao Zheng, Shuhan Huang, Yiyang Gong, Huabin Huang, Chengfeng Xiong, Da Huang,

https://doi.org/10.18632/aging.205736

View Abstract PDF Full-Text How to Cite

Activating transcription factor 6 alleviates secondary brain injury by increasing cystathionine γ-lyase expression in a rat model of intracerebral hemorrhage

Tianyu Liang, Sen Xu, Renyang Liu, Xiaoping Xia,

https://doi.org/10.18632/aging.205737

View Abstract PDF Full-Text How to Cite

Whole-transcriptome profiling reveals potential biomarkers for the reversal of thymic epithelial cell senescence by umbilical cord mesenchymal stem cells

Zai-Ling Yang, Chuan Tian, Jie He, Hang Pan, Guang-Ping Ruan, Jing Zhao, Kai Wang, Xing-Hua Pan, Xiang-Qing Zhu,

https://doi.org/10.18632/aging.205738

View Abstract PDF Full-Text How to Cite

Mining and exploration of rehabilitation nursing targets for colorectal cancer

Ruipu Li, Jie He, Zhijie Ni, Jie Zhang, Xiaoqian Chi, Chunbo Kang, Zhongbo Li, Xubin Li,

https://doi.org/10.18632/aging.205739

View Abstract PDF Full-Text How to Cite

Identification of biomarkers and immune infiltration characterization of lipid metabolism associated genes in osteoarthritis based on machine learning algorithms

Yuanye Ma, Yang Liu, Dan Luo, Zhu Guo, Hongfei Xiang, Bohua Chen, Xiaolin Wu,

https://doi.org/10.18632/aging.205740

View Abstract PDF Full-Text How to Cite

Keratin 6A (KRT6A) promotes radioresistance, invasion, and metastasis in lung cancer via p53 signaling pathway

Qiang Xu, Ziyang Yu, Qiteng Mei, Kejun Shi, Jiaofeng Shen, Guangyu Gao, Songtao Liu, Ming Li,

https://doi.org/10.18632/aging.205742

View Abstract PDF Full-Text How to Cite

Comprehensive characterization of β-alanine metabolism-related genes in HCC identified a novel prognostic signature related to clinical outcomes

Yi Jia, Xu Chen, Hui Guo, Biao Zhang, Bin Liu,

https://doi.org/10.18632/aging.205744

View Abstract PDF Full-Text How to Cite

An exploration of causal relationships between nine neurological diseases and the risk of breast cancer: a Mendelian randomization study

Fei Ren, Chenxuan Yang, Kexin Feng, Qingyao Shang, Jiaxiang Liu, Xiyu Kang, Xin Wang, Xiang Wang,

https://doi.org/10.18632/aging.205745

View Abstract PDF Full-Text How to Cite

Single session of intermittent theta burst stimulation alters brain activity of patients in vegetative state

Ying Huang, Xiaoyu Xia, Xiangqiang Meng, Yang Bai, Zhen Feng,

https://doi.org/10.18632/aging.205746

View Abstract PDF Full-Text How to Cite

Treatment patterns and survival in T4b esophageal cancer: a retrospective cohort study

Bin-Bin Yu, Jiang-Qiong Huang, Huan-Wei Liang, Yang Liu, Long Chen, Su Pei, Wei Huang, Xin-Bin Pan,

https://doi.org/10.18632/aging.205747

View Abstract PDF Full-Text How to Cite

Aberrant expression of thyroidal hormone receptor α exasperating mitochondrial dysfunction induced sarcopenia in aged mice

Yunlu Sheng, Xiaoxia Zhu, Lijun Wei, Yuxin Zou, Xinyu Qi, Runqing Shi, Wenli Xu, Xiaodong Wang, Guoxian Ding, Yu Duan,

https://doi.org/10.18632/aging.205748

View Abstract PDF Full-Text How to Cite

Ferulic acid in synergy with retinol alleviates oxidative injury of HaCaT cells during UVB-induced photoaging

Peng Shu, Jiaxin Mo, Zunjiang Li, Mingjie Li, Wei Zhu, Zhiyun Du,

https://doi.org/10.18632/aging.205749

View Abstract PDF Full-Text How to Cite

Integrative analysis based on the cell cycle-related genes identifies TPX2 as a novel prognostic biomarker associated with tumor immunity in breast cancer

Xinli Liu, Wenyi Wang, Bing Chen, Shengjie Wang,

https://doi.org/10.18632/aging.205752

View Abstract PDF Full-Text How to Cite

Hepatocyte-specific METTL3 ablation by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and postnatal lethality

Shihao Huang, Yingchun Li, Bingjie Wang, Zhihao Zhou, Yonglong Li, Lingjun Shen, Jinge Cong, Liuxin Han, Xudong Xiang, Jiawei Xia, Danhua He, Zhanlin Zhao, Ying Zhou, Qiwen Li, Guanqi Dai, Hanzhang Shen, Taoyan Lin, Aibing Wu, Junshuang Jia, Dong Xiao, Jing Li, Wentao Zhao, Xiaolin Lin,

https://doi.org/10.18632/aging.205753

View Abstract PDF Full-Text How to Cite

AAT resistance-related AC007405.2 and AL354989.1 as novel diagnostic and prognostic markers in prostate cancer

Yuanzhong Deng, Chunlin Zhang, Haitao Yu, Guo Chen, Xiang Peng, Yang Li, Zhenwei Feng, Wei Shi, Xuesong Bai, Xin Gou, Nian Liu,

https://doi.org/10.18632/aging.205754

View Abstract PDF Full-Text How to Cite

Biological significance of METTL5 in atherosclerosis: comprehensive analysis of single-cell and bulk RNA sequencing data

Jianjin Wu, Lei Wang, Shuaishuai Xi, Chao Ma, Fukang Zou, Guanyu Fang, Fangbing Liu, Xiaokai Wang, Lefeng Qu,

https://doi.org/10.18632/aging.205755

View Abstract PDF Full-Text How to Cite

Medium-chain chlorinated paraffins (MCCPs) induce renal cell aging and ferroptosis

Dong Zhang, Zongying Li, Yuan Gao, Hailing Sun,

https://doi.org/10.18632/aging.205756

View Abstract PDF Full-Text How to Cite

A novel prognostic signature based on cancer stemness and metabolism-related genes for cervical squamous cell carcinoma and endocervical adenocarcinoma

Yaokai Wang, Yuanyuan Han, Liangzi Jin, Lulu Ji, Yanxiang Liu, Min Lin, Sitong Zhou, Ronghua Yang,

https://doi.org/10.18632/aging.205757

View Abstract PDF Full-Text How to Cite

Integrated multi-omics analysis and machine learning identify hub genes and potential mechanisms of resistance to immunotherapy in gastric cancer

Jinsong Wang, Jia Feng, Xinyi Chen, Yiming Weng, Tong Wang, Jiayan Wei, Yujie Zhan, Min Peng,

https://doi.org/10.18632/aging.205760

View Abstract PDF Full-Text How to Cite

Heart failure potentially affects the cortical structure of the brain

Yinqin Hu, Tianyun Shi, Zhaohui Xu, Meng Zhang, Jiahui Yang, Zhirui Liu, Qiqi Wan, Yongming Liu,

https://doi.org/10.18632/aging.205762

View Abstract PDF Full-Text How to Cite

New insights from bidirectional Mendelian randomization: causal relationships between telomere length and mitochondrial DNA copy number in aging biomarkers

Xinyu Yan, Peixuan Yang, Yani Li, Ting Liu, Yawen Zha, Ting Wang, Jingjing Zhang, Zhijun Feng, Minying Li,

https://doi.org/10.18632/aging.205765

View Abstract PDF Full-Text How to Cite

Identification and validation of an anoikis-related genes signature for prognostic implication in papillary thyroid cancer

Runyu Zhao, Yingying Lu, Zhihan Wan, Peipei Qiao, Liyun Yang, Yi Zhang, Shuixian Huang, Xiaoping Chen,

https://doi.org/10.18632/aging.205766

View Abstract PDF Full-Text How to Cite

Identification of protein methyltransferases 5 associated with ferroptosis and immune cell infiltration of head and neck squamous cell carcinoma

Xiaoyue Zhang, Qiang Liu, Lujuan Wang, Qiu Peng,

https://doi.org/10.18632/aging.205768

View Abstract PDF Full-Text How to Cite

Comprehensive bioinformatics analysis of NOX4 as a biomarker for pan-cancer prognosis and immune infiltration

Yuying Liu, Hua Huang, Xijun Yang, Danhe Huang, Xiongwei Wang, Mingyu Yuan, Lianqing Hong,

https://doi.org/10.18632/aging.205769

View Abstract PDF Full-Text How to Cite

Exploring causality in the association between gut microbiota and irritable bowel syndrome risk: a large Mendelian randomization study

Jishi Zhang, Xinlin Shi, Yun Wang,

https://doi.org/10.18632/aging.205771

View Abstract PDF Full-Text How to Cite

Establishment and assessment of mortality risk prediction model in patients with sepsis based on early-stage peripheral lymphocyte subsets

Fuzhu Li, Hongtao Qu, Yimin Li, Jie Liu, Hongyun Fu,

https://doi.org/10.18632/aging.205772

View Abstract PDF Full-Text How to Cite

Mechanism of ameliorating cerebral ischemia/reperfusion injury by antioxidant inhibition of autophagy based on network pharmacology and experimental verification

Yuantie Zheng, Zhicheng Huang, Yang Zhao, Lili Huang, Jun Wang, Heping Li, Xing Chen, Jingsong Wang, Jingwen Xie,

https://doi.org/10.18632/aging.205773

View Abstract PDF Full-Text How to Cite

ANGPTL4, a direct target of hsa-miR-133a-3p, accelerates lung adenocarcinoma lipid metabolism, proliferation and invasion

Qihao Hu, Shi Chen, Yukun Li, Teng Hu, Jianpeng Hu, Cheng Wang, Fei Yang, Xiang Yang, Feng Zhou, Zhengdong Liu, Wei Xu, Ji Zhang,

https://doi.org/10.18632/aging.205313

View Abstract PDF Full-Text How to Cite

Teneligliptin alleviates diabetes-related cognitive impairment by inhibiting the endoplasmic reticulum (ER) stress and NLRP3 inflammasome in mice

Weifeng Wang, Juanjuan Zhang,

https://doi.org/10.18632/aging.205333

View Abstract PDF Full-Text How to Cite

Local anesthetic levobupivacaine induces ferroptosis and inhibits progression by up-regulating p53 in non-small cell lung cancer

Minghua Meng, Meiling Huang, Cuicui Liu, Jiming Wang, Weihua Ren, Shaomin Cui, Jianhua Gu, Jinlan Xie, Bin Ma, Guangzhu Yang, Shuncheng He,

https://doi.org/10.18632/aging.203138

View Abstract PDF Full-Text How to Cite

Identification of an immune subtype predicting survival risk and immune activity in hepatocellular carcinoma

Feng Zhao, Nuo Xu, Jiali Yang, Bo Li, Jianwei Shi, Yuanyuan Zheng, Longjin Xu,

https://doi.org/10.18632/aging.202953

View Abstract PDF Full-Text How to Cite

Featured Nobel Articles

Advance Online Publications

Research Papers

Michael D. Roberts, Bradley A. Ruple, Joshua S. Godwin, Mason C. McIntosh, Shao-Yung Chen, Nicholas J. Kontos, Anthony Agyin-Birikorang, Max Michel, Daniel L. Plotkin, Madison L. Mattingly, Brooks Mobley, Tim N. Ziegenfuss, Andrew D. Fruge, Andreas N. Kavazis,

Cite this Article

How to cite

Copy or Download citation:

Henry Raab, Elizabeth R. Hauser, Lydia Coulter Kwee, Svati H. Shah, William E. Kraus, Cavin K. Ward-Caviness,

Cite this Article

How to cite

Copy or Download citation:

Lindsay Pett, Zhenjiang Li, Sarina Abrishamcar, Kenyaita Hodge, Todd Everson, Grace Christensen, Marla Gearing, Michael S. Kobor, Chaini Konwar, Julia L. MacIsaac, Kristy Dever, Aliza P. Wingo, Allan Levey, James J. Lah, Thomas S. Wingo, Anke Hüls,

Cite this Article

How to cite

Copy or Download citation:

Alexandra G. Zonnefeld, Chang-Yi Cui, Dimitrios Tsitsipatis, Yulan Piao, Jinshui Fan, Krystyna Mazan-Mamczarz, Yutong Xue, Fred E. Indig, Supriyo De, Myriam Gorospe,

Cite this Article

How to cite

Copy or Download citation:

Shiyun Chen, Jingjing Li, Luda Yan, Xianhao Zhang, Jiesi Huang, Peng Zhou,

Cite this Article

How to cite

Copy or Download citation:

Lianjie Hou, Zhiming Zou, Yu Wang, Hui Pi, Zeyue Yuan, Qin He, Yongfang Kuang, Guojun Zhao,

Cite this Article

How to cite

Copy or Download citation:

Yun Li, Chenghang Jiang, Quanqi Liu, Pengfei Zhou, Daxue Tian, Ying Zeng, Mingfeng Xiang,

Cite this Article

How to cite

Copy or Download citation:

Meng Fan, Le Lu, Hao Shang, Yuxuan Lu, Yi Yang, Xiuyan Wang, Hongwei Lu,

Cite this Article

How to cite

Copy or Download citation:

Yongbin Di, Haolei Zhang, Bohao Zhang, Tianke Li, Dan Li,

Cite this Article

How to cite

Copy or Download citation:

Dongxiao Li, Min Wang,

Cite this Article

How to cite

Copy or Download citation:

Jiamu Lv, Yining Jiang, Tingting Yu, Shengrui Gao, Wanzhong Yin,

Cite this Article

How to cite

Copy or Download citation:

Jili Zhang, Zhihao Li, Zhenlin Chen, Wenzhen Shi, Yue Xu, Zhangcheng Huang, Zequn Lin, Ruiling Dou, Shaoshan Lin, Xin Jiang, Mengqiang Li, Shaoqin Jiang,

Cite this Article

How to cite

Copy or Download citation:

Qu Zhanbo, Zhuang Jing, Han Shugao, Wu Yinhang, Chu Jian, Yu Xiang, Zhao Feimin, Liu Jian, Wu Xinyue, Wu Wei, Han Shuwen,

Cite this Article

How to cite

Copy or Download citation:

Lei Hou, Zhongchen Li, Xiaoli Guo, Jiatao Lv, Zonglei Chong, Yilei Xiao, Liyong Zhang, Zefu Li,

Cite this Article

How to cite

Copy or Download citation:

Gang Du, Zhaochen Jiang, Tong Xia, Mingkun Liu, Zeyang Liu, Huaxin Zhou, Hao Zhang, Xiangyu Zhai, Bin Jin,

Cite this Article

How to cite

Copy or Download citation:

Hongshuo Shi, Zhicheng Zhang, Xin Yuan, Guobin Liu, Weijing Fan, Wenbo Wang,

Cite this Article

How to cite

Copy or Download citation:

Guohai Xiong, Jinmei Shan, Qingguo Chong, Yueqing Cui,

Cite this Article

How to cite

Copy or Download citation:

Fei Gao, Shuangjiao Deng, Yujin Liu, Pengcheng Wu, Lifen Huang, Feng Zhu, Chunzhu Wei, Yuyi Yuan, Yang Gui, Yushi Tian, Heng Fan, Hui Wu,

Cite this Article

How to cite

Copy or Download citation:

Ya-Nan Cui, Na Tian, Yan-Hai Luo, Ji-Jun Zhao, Cheng-Fei Bi, Yi Gou, Jia Liu, Ke Feng, Jun-Fei Zhang,

Cite this Article

How to cite

Copy or Download citation:

Yongqi Ding, Yike Jiang, Hong Zeng, Minqin Zhou, Xuanrui Zhou, Zichuan Yu, Jingying Pan, Xitong Geng, Yanting Zhu, Hao Zheng, Shuhan Huang, Yiyang Gong, Huabin Huang, Chengfeng Xiong, Da Huang,