Advance Online Publications

Table of Contents

Editorials

Senescent cells enhance ischemic aging in the female heart

Daniele Torella, Nadia Salerno, Eleonora Cianflone,

https://doi.org/10.18632/aging.204585

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Repurposing Canagliflozin to target brain aging

Hashan Jayarathne, Wanqing Liu, Marianna Sadagurski,

https://doi.org/10.18632/aging.204624

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3-Deazaadenosine keeps senescence at bay

Ana Guerrero, Jesús Gil,

https://doi.org/10.18632/aging.204625

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A novel system to analyze oral frailty of mice

Tetsuya Goto, Eriko Kuramoto, Ayano Kitawaki,

https://doi.org/10.18632/aging.204568

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Anaphase II processes contribute to aneuploidy in aging oocytes

Anna Kouznetsova,

https://doi.org/10.18632/aging.204640

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Artificial intelligence and the aging mind

Jeyeon Lee, Leland R. Barnard, David T. Jones,

https://doi.org/10.18632/aging.204644

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Mitochondrial redox signaling: a key player in aging and disease

Maria Vitale, Alberto Sanz, Filippo Scialò,

https://doi.org/10.18632/aging.204659

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Commentary

Sex-specific hippocampal connectivity markers in mild cognitive impairment

Yuan Yang, Andriy Yabluchanskiy,

https://doi.org/10.18632/aging.204660

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Research Papers

DNAmFitAge: biological age indicator incorporating physical fitness

Kristen M. McGreevy, Zsolt Radak, Ferenc Torma, Matyas Jokai, Ake T. Lu, Daniel W. Belsky, Alexandra Binder, Riccardo E. Marioni, Luigi Ferrucci, Ewelina Pośpiech, Wojciech Branicki, Andrzej Ossowski, Aneta Sitek, Magdalena Spólnicka, Laura M. Raffield, Alex P. Reiner, Simon Cox, Michael Kobor, David L. Corcoran, Steve Horvath,

https://doi.org/10.18632/aging.204538

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Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic

Fares Al-Mansour, Abdullah Alraddadi, Buwei He, Anes Saleh, Marta Poblocka, Wael Alzahrani, Shaun Cowley, Salvador Macip,

https://doi.org/10.18632/aging.204616

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Increased expression of musashi 1 on breast cancer cells has implication to understand dormancy and survival in bone marrow

George R. Nahas, Lauren S. Sherman, Garima Sinha, Markos H. El Far, Andrew Petryna, Steven M. Munoz, Kimberly A. Silverio, Maran Shaker, Pujan Neopane, Veronica Mariotti, Pranela Rameshwar,

https://doi.org/10.18632/aging.204620

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p21 facilitates chronic lung inflammation via epithelial and endothelial cells

Naama Levi, Nurit Papismadov, Julia Majewska, Lior Roitman, Noa Wigoda, Raya Eilam, Michael Tsoory, Ron Rotkopf, Yossi Ovadya, Hagay Akiva, Ofer Regev, Valery Krizhanovsky,

https://doi.org/10.18632/aging.204622

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Effect of deferoxamine and ferrostatin-1 on salivary gland dysfunction in ovariectomized rats

Yong-Il Cheon, Ji Min Kim, Sung-Chan Shin, Hyung-Sik Kim, Jin-Choon Lee, Gi Cheol Park, Eui-Suk Sung, Minhyung Lee, Byung-Joo Lee,

https://doi.org/10.18632/aging.204641

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Viral vector-mediated upregulation of serine racemase expression in medial prefrontal cortex improves learning and synaptic function in middle age rats

Brittney Yegla, Asha Rani, Ashok Kumar,

https://doi.org/10.18632/aging.204652

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LINC01296 promotes proliferation of cutaneous malignant melanoma by regulating miR-324-3p/MAPK1 axis

Kang Wang, Qing Luo, Yingfeng Zhang, Xin Xie, Wenhao Cheng, Qiunan Yao, Yingying Chen, Hong Ren, Jiuping Li, Zuanqin Pan,

https://doi.org/10.18632/aging.204413

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Placenta autophagy is closely associated with preeclampsia

Chaomei Li, Wei Liu, Qunxiu Lao, Haiying Lu, Yingting Zhao,

https://doi.org/10.18632/aging.204436

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FKBP11 improves the malignant property of osteosarcoma cells and acts as a prognostic factor of osteosarcoma

Duo Zeng, Jiayu Li, Xuhui Yuan, Feng Cai, Bo Yu, Lang Liu, Qinchan Chen, FeiFei Zhang, Yiping Liang, Xiaofeng Tang, Yuanxiang Peng, Gaoyang Qu, Pengyun Wu, QuanHui Jiao, Longhua Sun, Xiao-Bin Lv, Qi Liao,

https://doi.org/10.18632/aging.

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Senescence-related genes define prognosis, immune contexture, and pharmacological response in gastric cancer

Xiaogang Shen, Meng Wang, Wenxi Chen, Yu Xu, Qiaoxia Zhou, Tengfei Zhu, Guoqiang Wang, Shangli Cai, Yusheng Han, Chunwei Xu, Wenxian Wang, Lei Meng, Hao Sun,

https://doi.org/10.18632/aging.204524

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PI3K-Akt signaling pathway based on network pharmacology for the anti-Alzheimer’s disease effect of licorice stem flavonoids

Hongyan Pei, Lei He, Meiling Shi, Xiangjuan Guo, Weijia Chen, Jianming Li, Zhongmei He, Rui Du,

https://doi.org/10.18632/aging.204536

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Relationship between advanced maternal age and decline of endometrial receptivity: a systematic review and meta-analysis

Jing Zhao, Bixia Huang, Ning Li, Xiaofei Wang, Bin Xu, Yanping Li,

https://doi.org/10.18632/aging.204555

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ESM1 promotes angiogenesis in colorectal cancer by activating PI3K/Akt/mTOR pathway, thus accelerating tumor progression

Liqun Yang, Zhigang Dong, Shuyu Li, Tieliang Chen,

https://doi.org/10.18632/aging.204559

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NRP1 regulates autophagy and proliferation of gastric cancer through Wnt/β-catenin signaling pathway

Qi-Ying Yu, Yue Han, Jia-Hui Lu, Yan-Jie Sun, Xing-Hua Liao,

https://doi.org/10.18632/aging.204560

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lncRNA PITPNA-AS1 promotes cell proliferation and metastasis in hepatocellular carcinoma by upregulating PDGFD

Jianguo Yao, Xiaojian Liu,

https://doi.org/10.18632/aging.204566

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GRB10 is a novel factor associated with gastric cancer proliferation and prognosis

Li-Li Ren, Zhi-Wen Wang, Ren Sen, Zhou-Tong Dai, Xing-Hua Liao, Li-Juan Shen,

https://doi.org/10.18632/aging.204603

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High expression of serine protease 2 (PRSS2) associated with invasion, metastasis, and proliferation in gastric cancer

Haifeng Qin, Shushu Zhang, Linling Shen, Chenjian Mao, Guangyu Gao, Hui Wang,

https://doi.org/10.18632/aging.204604

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NR5A2 as a potential target for exercise to improve metabolic syndrome

Lingxiu Meng, Fusheng Dong, Junguo Deng,

https://doi.org/10.18632/aging.204606

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FARSB serves as a novel hypomethylated and immune cell infiltration related prognostic biomarker in hepatocellular carcinoma

Jing Zhen, Jingying Pan, Xuanrui Zhou, Zichuan Yu, Yike Jiang, Yiyang Gong, Yongqi Ding, Yue Liu, Liangyun Guo,

https://doi.org/10.18632/aging.204619

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NCAPG as a novel prognostic biomarker in numerous cancers: a meta-analysis and bioinformatics analysis

Jie Lin, Gangyi Li, Yanping Bai, Yingjun Xie,

https://doi.org/10.18632/aging.204621

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RNA helicase DDX5-induced circPHF14 promotes gastric cancer cell progression

Jia Wang, Chunjie Han, Jinsheng Wang, Qiu Peng,

https://doi.org/10.18632/aging.204623

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Identification and validation of anoikis-associated gene SNCG as a prognostic biomarker in gastric cancer

Yi Li, Qin Pan, Mingxia Cheng, Zhengyuan Wu,

https://doi.org/10.18632/aging.204626

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Neuroprotective effect of total flavonoids in stems and leaves of Glycyrrhiza uralensis Fisch. on oxidative stress in HT-22 cells and Caenorhabditis elegans

Weijia Chen, Lei He, Hongyan Pei, Jianming Li, Yan Zhao, Ying Zong, Hong Kan, Zhongmei He, Rui Du,

https://doi.org/10.18632/aging.204627

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Sirt3 regulates NLRP3 and participates in the effects of plantainoside D on acute lung injury sepsis

Jing Wang, Wanrong Li, Fang Zhao, Qianqian Han, Lingling Shan, Yumei Qian,

https://doi.org/10.18632/aging.204628

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Th1 promotes M1 polarization of intestinal macrophages to regulate colitis-related mucosal barrier damage

Shuiliang Ruan, Liang Xu, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Caiqun Zhang, Li Guo, Wenyan Li, Chenyang Han,

https://doi.org/10.18632/aging.204629

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A novel inflammation-related signature for predicting prognosis and characterizing the tumor microenvironment in colorectal cancer

Jinna Li, Jiapeng Yang, Rui Xing, Ying Wang,

https://doi.org/10.18632/aging.204630

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Allograft inflammatory factor 1 is a potential diagnostic, immunological, and prognostic biomarker in pan-cancer

Xin Liu, Dandan Zhang, Jianping Hu, Sikai Xu, Chengyun Xu, Yang Shen,

https://doi.org/10.18632/aging.204631

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Bioinformatics analysis and experimental validation of a novel autophagy-related signature relevant to immune infiltration for recurrence prediction after curative hepatectomy

Huaxiang Wang, Chengkai Yang, Dong Li, Ruling Wang, Yanbing Li, Lizhi Lv,

https://doi.org/10.18632/aging.204632

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Development and validation of a novel anoikis-related gene signature for predicting prognosis in ovarian cancer

Shuangfeng Qian, Yidan Wen, Lina Mei, Xiaofu Zhu, Hongtao Zhang, Chunyan Xu,

https://doi.org/10.18632/aging.204634

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Biological function analysis of ARHGAP39 as an independent prognostic biomarker in hepatocellular carcinoma

Yongqi Ding, Yiyang Gong, Hong Zeng, Xuanrui Zhou, Zichuan Yu, Jingying Pan, Minqin Zhou, Shiwen Liu, Wei Lai,

https://doi.org/10.18632/aging.204635

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Machine learning-based construction of immunogenic cell death-related score for improving prognosis and response to immunotherapy in melanoma

Guoyin Li, Huina Zhang, Jin Zhao, Qiongwen Liu, Jinke Jiao, Mingsheng Yang, Changjing Wu,

https://doi.org/10.18632/aging.204636

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Long noncoding RNA POU6F2-AS2 contributes to the aggressiveness of nonsmall-cell lung cancer via microRNA-125b-5p-mediated E2F3 upregulation

Haitao Yang, Xiao Feng, Xiangdong Tong,

https://doi.org/10.18632/aging.204639

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Berberine mitigates intracerebral hemorrhage-induced neuroinflammation in a gut microbiota-dependent manner in mice

Jing Liu, Haotian Chen, Ting Yu, Xiongjie Fu, Cong Qian, Xiuqin Feng,

https://doi.org/10.18632/aging.204642

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Pioglitazone reduces cardiovascular events and dementia but increases bone fracture in elderly patients with type 2 diabetes mellitus: a national cohort study

Chieh-Li Yen, Chao-Yi Wu, Chung-Ying Tsai, Cheng-Chia Lee, Yi-Jung Li, Wei-Sheng Peng, Jia-Rou Liu, Yuan-Chang Liu, Chang-Chyi Jenq, Huang-Yu Yang, Lai-Chu See,

https://doi.org/10.18632/aging.204643

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Comprehensive analysis reveals TSEN54 as a robust prognosis biomarker and promising immune-related therapeutic target for hepatocellular carcinoma

Bidong Fu, Minqin Zhou, Gelin Song, Hong Zeng, Yiyang Gong, Yike Jiang, Yun Ke, Da Huang, Hong Peng, Qing Li,

https://doi.org/10.18632/aging.204645

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Comprehensive analysis of cuproptosis-related immune biomarker signature to enhance prognostic accuracy in gastric cancer

Jie Li, Tian Yu, Juan Sun, Ziyang Zeng, Zhen Liu, Mingwei Ma, Zicheng Zheng, Yixuan He, Weiming Kang,

https://doi.org/10.18632/aging.204646

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Long non-coding RNA HOXA11-AS regulates ischemic neuronal death by targeting miR-337-3p/YBX1 signaling pathway: protective effect of dexmedetomidine

Fei Yan, Pinxiao Wang, Xiaojian Yang, Fuli Wang,

https://doi.org/10.18632/aging.204648

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Ubiquitin-proteasome system-mediated ubiquitination modification patterns and characterization of tumor microenvironment infiltration, stemness and cellular senescence in low-grade glioma

Jun Gu, Lijun Pang, Donghua Yan, Chunming Wang, Yuekun Song, Zhengshuai Jin, Zhenwei Xu, Yuanqing Mao, Shengzhe Liu, Sheng Chen,

https://doi.org/10.18632/aging.204650

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Upregulation of RasGRF1 ameliorates spatial cognitive dysfunction in mice after chronic cerebral hypoperfusion

Li-Jie Yang, Wei Wu, Wan-Rong Jiang, Cheng-Liang Zhu, Zhao-Hui Yao,

https://doi.org/10.18632/aging.204654

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Protective effect of fluoxetine against oxidative stress induced by renal ischemia-reperfusion injury via the regulation of miR-450b-5p/Nrf2 axis

Zhiqiang Qin, Hao Wang, Quanliang Dou, Luwei Xu, Zheng Xu, Ruipeng Jia,

https://doi.org/10.18632/aging.204289

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A regulatory circuit of lncRNA NLGN1-AS1 and Wnt signalling controls clear cell renal cell carcinoma phenotypes through FZD4-modulated pathways

Haifeng Gao, Wei Chen, Gaojian Pan, Hui Liu, Jinke Qian, Weijun Tang, Wei Wang, Shilei Qian,

https://doi.org/10.18632/aging.204263

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Local anesthetic levobupivacaine induces ferroptosis and inhibits progression by up-regulating p53 in non-small cell lung cancer

Minghua Meng, Meiling Huang, Cuicui Liu, Jiming Wang, Weihua Ren, Shaomin Cui, Jianhua Gu, Jinlan Xie, Bin Ma, Guangzhu Yang, Shuncheng He,

https://doi.org/10.18632/aging.203138

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Identification of an immune subtype predicting survival risk and immune activity in hepatocellular carcinoma

Feng Zhao, Nuo Xu, Jiali Yang, Bo Li, Jianwei Shi, Yuanyuan Zheng, Longjin Xu,

https://doi.org/10.18632/aging.202953

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