Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

Ivan Montoliu; Max Scherer; Fiona Beguelin; Laeticia DaSilva; Daniela Mari; Stefano Salvioli; François-Pierre J. Martin; Miriam Capri; Laura Bucci; Rita Ostan; Paolo Garagnani; Daniela Monti; Elena Biagi; Patrizia Brigidi; Martin Kussmann; Serge Rezzi; Claudio Franceschi; Sebastiano Collino

doi:doi:10.18632/aging.100630

Research Paper Volume 6, Issue 1 pp 9—25

Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

Ivan Montoliu^1,, Max Scherer^2,, Fiona Beguelin^2,, Laeticia DaSilva^2,, Daniela Mari^3,4,, Stefano Salvioli^5,6,, François-Pierre J. Martin^2,, Miriam Capri^5,6,, Laura Bucci^5,6,, Rita Ostan^5,6,, Paolo Garagnani^5,6,, Daniela Monti^7,, Elena Biagi^8,, Patrizia Brigidi^8,, Martin Kussmann^2,9,10,, Serge Rezzi^2,, Claudio Franceschi^5,6,, Sebastiano Collino^2,,

¹ NESTEC SA, Nestlé Research Center, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland
² Nestlé Institute of Health Sciences SA, Campus EPFL, Molecular Biomarkers Core, Quartier de l'innovation, CH-1015 Lausanne, Switzerland
³ Department of Medical Sciences, University of Milan, Milan, Italy
⁴ Geriatric Unit IRCCS Ca' Grande Foundation Maggiore Policlinico Hospital, Milan, Italy
⁵ Department of Experimental, Diagnostic and Specialty Medicine Experimental Pathology, University of Bologna, Via S. Giacomo 12, 40126 Bologna, Italy
⁶ Interdepartmental Centre “L. Galvani” CIG, University of Bologna, Piazza di Porta S. Donato 1, 40126 Bologna, Italy
⁷ Department of Clinical, Experimental and Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
⁸ Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
⁹ Faculty of Life Sciences, Ecole Polytechnique Fédérale Lausanne (EPFL), Lausanne, Switzerland
¹⁰ Faculty of Science, Interdisciplinary NanoScience Center (iNANO), Aarhus University, Aarhus, Denmark

Received: December 5, 2013 Accepted: January 19, 2014 Published: January 21, 2014

https://doi.org/10.18632/aging.100630
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Montoliu I, Scherer M, Beguelin F, DaSilva L, Mari D, Salvioli S, Martin FJ, Capri M, Bucci L, Ostan R, Garagnani P, Monti D, Biagi E, et al, . Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity. Aging (Albany NY). 2014; 6:9-25. https://doi.org/10.18632/aging.100630

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        TY  - JOUR
        AU  - Montoliu, Ivan 
        AU  - Scherer, Max 
        AU  - Beguelin, Fiona 
        AU  - DaSilva, Laeticia 
        AU  - Mari, Daniela 
        AU  - Salvioli, Stefano 
        AU  - Martin, François-Pierre J. 
        AU  - Capri, Miriam 
        AU  - Bucci, Laura 
        AU  - Ostan, Rita 
        AU  - Garagnani, Paolo 
        AU  - Monti, Daniela 
        AU  - Biagi, Elena 
        AU  - Brigidi, Patrizia 
        AU  - Kussmann, Martin 
        AU  - Rezzi, Serge 
        AU  - Franceschi, Claudio 
        AU  - Collino, Sebastiano 
        TI  - Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity
        JO  - 
        JA  - Aging (Albany NY)
        VL  - 6
        IS  - 1
        PB  - 
        SN  - 
        UR  - https://doi.org/10.18632/aging.100630
        DO  - 10.18632/aging.100630
        SP  - 9
        EP  - 25
        PY  - 
        AB  - As centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metabolome and lipidome composition of a group of centenarians with respect to elderly individuals. Specifically, NMR metabonomics profiling of serum revealed that centenarians are characterized by a metabolic phenotype distinct from that of elderly subjects, in particular regarding amino acids and lipid species. Shot- gun lipidomics approach displays unique changes in lipids biosynthesis in centenarians, with 41 differently abundant lipid species with respect to elderly subjects. These findings reveal phospho/sphingolipids as putative markers and biological modulators of healthy aging, in humans. Considering the particular actions of these metabolites, these data are suggestive of a better counteractive antioxidant capacity and a well-developed membrane lipid remodelling process in the healthy aging phenotype.
        ER  -

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Abstract

As centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metabolome and lipidome composition of a group of centenarians with respect to elderly individuals. Specifically, NMR metabonomics profiling of serum revealed that centenarians are characterized by a metabolic phenotype distinct from that of elderly subjects, in particular regarding amino acids and lipid species. Shot- gun lipidomics approach displays unique changes in lipids biosynthesis in centenarians, with 41 differently abundant lipid species with respect to elderly subjects. These findings reveal phospho/sphingolipids as putative markers and biological modulators of healthy aging, in humans. Considering the particular actions of these metabolites, these data are suggestive of a better counteractive antioxidant capacity and a well-developed membrane lipid remodelling process in the healthy aging phenotype.

Research Paper Volume 6, Issue 1 pp 9—25

Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

Received: December 5, 2013 Accepted: January 19, 2014 Published: January 21, 2014

Abstract

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